Completion of the swine genome will simplify the production of swine as a large animal biomedical model

BMC Medical Genomics

Randall S Prather²  Lela K Riley²  John K Critser²  Kevin D Wells²  Jianguo Zhao²  Eiji Kobayashi³  Hiroshi Nagashima¹  Simone Renner⁴  Jiude Mao²  Jeffery J Whyte²  Eckhard Wolf⁴  Eric M Walters² 

[1] Laboratory of Developmental Engineering, Meiji University, 1-1-1 Higashimita, Tama, Kawasaki, 214-8571, Japan;National Swine Resource and Research Center, University of Missouri, 920 E. Campus Dr, Columbia, MO, 65211, USA;Center for Development of Advanced Technology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi-ken, 329-0498, Japan;Molecular Animal Breeding and Biotechnology, Department of Veterinary Sciences and Laboratory for Functional Genome Analysis, Feoder-Lynen-Strasse 250, Munich, 81377, Germany

关键词: Human diseases;    Genetically engineered;    Biomedical model;    Pig;    Genomic;   

Others  :  1134558
DOI  :  10.1186/1755-8794-5-55

 received in 2011-06-08, accepted in 2011-10-28,  发布年份 2012

【 摘 要 】

Background

Anatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease.

Methods

Cloning from a modified somatic cell, which can be determined in cells prior to making the animal, is the only method available for the production of targeted modifications in swine.

Results

Since some strains of swine are similar in size to humans, technologies that have been developed for swine can be readily adapted to humans and vice versa. Here the importance of swine as a biomedical model, current technologies to produce genetically enhanced swine, current biomedical models, and how the completion of the swine genome will promote swine as a biomedical model are discussed.

Conclusions

The completion of the swine genome will enhance the continued use and development of swine as models of human health, syndromes and conditions.

【 授权许可】

   
2012 Walters et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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