Association of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 with chronic kidney disease

BMC Nephrology

Jing Chen¹  Jiang He¹  Eric E. Simon⁴  Vecihi Batuman⁴  Nader Rifai³  Kamal Shah²  Yanxi Liu¹  Chung-Shiuan Chen¹  Federico J. Teran²  L. Lee Hamm⁴  Faheemuddin A. Ahmed²  Belinda T. Lee² 

[1] Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA;Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA;Department of Laboratory Medicine, Children’s Hospital, Harvard School of Medicine, Boston, MA, USA;Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA

关键词: Tumor necrosis factor-alpha;    Interleukin-6;    Inflammation;    Choric kidney disease;    C-reactive protein;   

Others  :  1220085
DOI  :  10.1186/s12882-015-0068-7

 received in 2014-11-20, accepted in 2015-05-20,  发布年份 2015

【 摘 要 】

Background

We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD).

Methods

We conducted a case–control study among 201 CKD patients and 201 community-based controls in the greater New Orleans area. CKD was defined as estimated-glomerular filtration rate (eGFR) <60 mL/min/1.73 m² or albuminuria ≥30 mg/24-h. Serum CRP, TNF-α, and IL-6 were measured using standard methods. Multivariable regression models were used to examine associations between the inflammatory biomarkers and CKD adjusting for important CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.

Results

The multivariable-adjusted medians (interquartile-range) were 2.91 (1.47, 5.24) mg/L in patients with CKD vs. 1.91 (0.99, 3.79) mg/L in controls without CKD (p = 0.39 for group difference) for CRP; 1.86 (1.51, 2.63) pg/mL vs. 1.26 (1.01, 1.98) pg/mL (p < 0.0001) for TNF-α; and 2.53 (1.49, 4.42) pg/mL vs. 1.39 (0.95, 2.15) pg/mL (p = 0.04) for IL-6, respectively. Compared to the lowest tertile, the highest tertile of TNF-α (OR 7.1, 95 % CI 3.2 to 15.5) and IL-6 (OR 2.5, 95 % CI 1.1 to 5.5) were significantly associated with higher odds of CKD in multivariable-adjusted models. Additionally, higher TNF-α and IL-6 were independently and significantly associated with lower eGFR and higher albuminuria.

Conclusions

Our data suggest that TNF-α and IL-6, but not CRP, are associated with the prevalence and severity of CKD, independent from established CKD risk factors, history of cardiovascular disease, and use of antihypertensive, antidiabetic, and lipid-lowering agents and aspirin.

【 授权许可】

   
2015 Lee et al.; licensee BioMed Central.

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