Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study

BMC Public Health

Chengjun Sun¹  Jing Zeng²  Hui Huang²  Yang Liu² 

[1] Department of Physics and Chemistry, School of Public Health, Sichuan University, Chengdu 610041, China;Department of Endocrinology, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, Sichuan Province 610041, China

关键词: Cross-sectional study;    Thyroid disease;    Thyroid goiter;    Thyroid volume;    Thyroid hormones;    Selenium;    Iodine;   

Others  :  1161472
DOI  :  10.1186/1471-2458-13-1153

 received in 2012-10-29, accepted in 2013-12-04,  发布年份 2013

【 摘 要 】

Background

Selenium (Se) is a necessary element for the biosynthesis of thyroid hormones. We investigated the relationship between selenium status, thyroid volume, and goiter in a cross-sectional study in an iodine-sufficient area.

Methods

We selected residents of Chengdu (over 18 years old and living in the city for more than 5 years) using a stratified cluster sampling technique. Fifteen hundred subjects were selected for the study, which involved a questionnaire survey, physical examination, thyroid ultrasound, serum thyroid function test, and determination of serum selenium level. Thyroid volume was calculated from the thickness, width, length, and a corrective factor for each lobe. Ultimately, 1,205 subjects completed the investigation and were included in our study. Additionally, 80 school-age children were selected to provide urine samples for urinary iodine analysis. We analyzed the data using appropriate nonparametric and parametric statistical tests.

Results

The median urinary iodine value was 184 μg/L in school-age children, indicating iodine sufficiency. The median serum selenium level of the 1,205 subjects was 52.63 (interquartile range [IQR] : 40.40-67.00) μg/L. The median thyroid volume was 9.93 (IQR: 7.71-12.57) mL; both log-transformed serum selenium and log-transformed thyroid volume were Gaussian distributions (P = .638 and P = .046, respectively). The prevalences of goiter and thyroid nodules were 8.8% and 18.6%. The prevalences of positive thyroid autoantibodies, thyroperoxidase autoantibodies and thyroglobulin autoantibodies were 16.7%, 12.0%, and 11.1%, respectively. In the general linear regression model, there were positive associations between serum selenium and age, and body mass index. We found no association between serum selenium and thyroid-stimulating hormone. In simple linear regression analyses, we found no association between thyroid volume and serum selenium. There were no significant differences in serum selenium between persons with or without goiter. Serum selenium was not a risk factor for goiter.

Conclusion

In our study population, serum selenium was neither associated with thyroid volume nor with goiter in an iodine-sufficient area. More studies should be conducted by following non-goitrous persons over time and monitoring their selenium status.

【 授权许可】

   
2013 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Kohrle J: The trace element selenium and the thyroid gland. Biochimie 1999, 81(5):527-533.
• [2]Beckett GJ, Arthur JR: Selenium and endocrine systems. J Endocrinol 2005, 184(3):455-465.
• [3]Kohrle J, Brigelius-Flohe R, Bock A, et al.: Selenium in biology: facts and medical perspectives. Biol Chem 2000, 381(9–10):849-864.
• [4]Aydin K, Kendirci M, Kurtoglu S, et al.: Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. J Pediatr Endocrinol Metab 2002, 15(7):1027-1031.
• [5]Giray B, Hincal F, Tezic T, Okten A, Gedik Y: Status of selenium and antioxidant enzymes of goitrous children is lower than healthy controls and nongoitrous children with high iodine deficiency. Biol Trace Elem Res 2001, 82(1–2):35-52.
• [6]Giray B, Hincal F: DNA base damage, antioxidant enzyme activities and selenium status in highly iodine-deficient goitrous children. Free Radic Res 2002, 36(1):55-62.
• [7]Samir M, El Awady MY: Serum selenium levels in multinodular goitre. Clin Otolaryngol Allied Sci 1998, 23(6):512-514.
• [8]Brauer VF, Brauer WH, Fu¨hrer D, Paschke R: Iodine nutrition, nodular thyroid disease and urinary iodine excretion in a German university study population. Thyroid 2005, 15(4):364-370.
• [9]Laurberg P, Bulow Pedersen I, Knudsen N, Ovesen L, Andersen S: Environmental iodine intake affects the type of nonmalignant thyroid disease. Thyroid 2001, 11(5):457-469.
• [10]Brunn J, Block U, Ruf G, et al.: 1981 Volumetrieder Schilddrüsenlappen mittels Real-time-Sono-graphie [Volumetric analysis of thyroid lobes by real-time ultrasound]. Dtsch Med Wschr 1981, 106(41):409-414.
• [11]Zhang B, Yang L, Wang W: Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau. China. Environ Geochem Health 2011, 33(5):495-501.
• [12]Doupis J, Stavrianos C, Saltiki K: Thyroid volume, selenium levels and nutritional habits in a rural region in Albania. Hormones (Athens) 2009, 8(4):296-302.
• [13]Na LI, Zhi-dong GAO, De-gang LUO, Xun TANG, Da-fang CHEN, Yong-hua HU: Environmental and residents’serum selenium levels in Zhoukoudian Area of Beijing. Capital Journal of Public Health 2007, 1(1):13-17.
• [14]Ning LI, Zheng ZHANG, Hong-qun ZHANG, Xi-bao GAO: Dietary Se intake and serum Se reference value of Jinan residents. Journal of Shandong University (Health Sciences). 2009, 6(47):121-123.
• [15]Clark NA, Teschke K, Rideout K, et al.: Trace element levels in adults from the west coast of Canada and associations with age, gender, diet, activities, and levels of other trace elements [J]. Chemosphere 2007, 70(1):155-164.
• [16]Kafai MR, Ganji V: Sex, age, geographical location, smoking, and alcohol consumption in fluence serum selenium concentrations in the USA: Third national health and nutrition exami -nation survey, 1988–1994 [J]. J Trace Elem Med Biol 2003, 17(1):13-18.
• [17]Cinaz P, Karakasu DS, Camurdan MO, et al.: Goiter prevalence, serum selenium, and urine iodine status in a previously iodine-deficient area in Turkey. Biol Trace Elem Res 2004, 100(3):185-193.
• [18]Corvillian B, van Sande J, Laurent E, Dumont JE: The H2O2-generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. Endocrinology 1991, 128:779-785.
• [19]Goyens P, Golstein J, Nsombola B, Vis H, Dumont JE: Selenium deficiency as apossible factor in the pathogenesis of myxoedematous endemic cretinism. Acta Endocrinol 1987, 114(4):497-502.
• [20]Weiping Teng MD, Zhongyan Shan PD, Xiaochun Teng MD: Effect of iodine intake on thyroid diseases in China. N Engl J Med 2006, 354(26):2783-2793.
• [21]Lone Banke R, Lutz S: Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency. Eur J Endocrinol 2011, 164(4):585-590.
• [22]Erdoğan MF, Erdoğan G, Sav H, Güllü S, Kamel N: Endemic goiter. thiocyanate overload, and selenium status in school-age children. Biol Trace Elem Res 2001, 79(2):121-130.
• [23]Keshteli AH, Siavash MHM, Amini M: Selenium deficiency as a possible contributor of goiter in schoolchildren of Isfahan, Iran. Biol Trace Elem Res 2009, 129(1–3):70-77.
• [24]Hampel R, Kulberg T, Klein K, Jerichow JU, Pichmann EG, Clausen V, Schmidt I: Goiter incidence in Germany is greater than previously suspected. Med Klin 1995, 90(6):324-329.
• [25]Robinson MF, Thomson CD, Jenkinson CP, Luzhen G, Whanger PD: Long-term supplementation with selenate and selenomethionine: urinary excretion by New Zealand women. Br J Nutr 1997, 77(4):551-563.
• [26]Sanz Alaejos M, Diaz RC: Urinary selenium concentrations. Clin Chem 1993, 39(10):2040-2052.
• [27]Ozata M, Sakl M, Aydin A, et al.: Iodine and zinc, but Not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. Biol Trace Elem Res 1999, 69(3):211-216.
• [28]Volker FH B, Ulrich S, Josef Kohrle1, Ralf P: Selenium and goiter prevalence in borderline iodine sufficiency. Eur J Endocrinol 2006, 155(6):807-812.