Prevalence and risk factors for cervical neoplasia: a cervical cancer screening program in Beijing

BMC Public Health

Xiuhua Guo¹  Zihe Zheng¹  Wei Wang²  Yanxia Luo¹  Lijuan Wu¹  Lei Pan¹  Qi Gao¹  Xia Li¹  Lili Han³  Lixin Tao¹ 

[1] Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China;School of Medical Science, Edith Cowan University, Perth, Australia;Beijing Obstetrics and Gynecology Hospital, Beijing, China

关键词: High-grade cervical squamous intraepithelial lesions;    Risk factor;    Screening program;    Cervical cancer;   

Others  :  1122939
DOI  :  10.1186/1471-2458-14-1185

 received in 2013-04-09, accepted in 2014-11-06,  发布年份 2014

【 摘 要 】

Background

Cervical cancer is the second most common cancer and cause of cancer-related death for women worldwide. The aims of this study were to investigate the prevalence of cervical neoplasia and examine factors associated with high-grade cervical squamous intraepithelial lesions (HSIL) among women taking part in a cervical cancer screening program in Beijing.

Methods

Women aged 25–65 years were screened using the ThinPrep cytologic test and gynecologic examination. Univariate and multivariate logistic regressions were conducted to investigate factors associated with HSIL.

Results

Among 728,704 women screened, the prevalence of cervical intraepithelial neoplasia (CIN) I, II, III was 50.2, 34.0, and 36.4 per 100,000, respectively. Prevalence of cervical cancer was 12.2 per 100,000. Risk factors for HSIL included being in age group of 46–55 years (adjusted odds ratio [aOR] = 1.15, 95% CI: 1.07–1.44, compared with the 25–35 age group), bleeding after intercourse (aOR = 2.08, 95% CI: 1.40–3.10), and presence of trichomonas vaginalis infection (aOR = 2.62, 95% CI: 1.35–5.07), cervical inflammation (aOR = 4.22, 95% CI: 3.39–5.26), and genital warts (aOR = 3.89, 95% CI: 2.54–7.70). High education level (college and above compared with junior middle school or lower) was found to be protective (aOR = 0.79, 95% CI: 0.37–0.90).

Conclusions

The prevalence of cervical neoplasia is relatively high in Beijing. Women aged 46–55 years, those with a lower education level, those reporting bleeding after intercourse, and those affected by Trichomonas vaginalis infection, cervical inflammation and genital warts are at higher risk for HSIL. Particular efforts should be made to ensure these women are included in cervical cancer screening programs.

【 授权许可】

   
2014 Tao et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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