Phosphodiesterase 8B gene polymorphism in women with recurrent miscarriage: A retrospective case control study

BMC Medical Genetics

Helena Åkerud²  Anna-Karin Wikström²  Inger Sundström-Poromaa²  Britth-Marie Landgren¹  Katarina Bremme³  Anneli Stavreus-Evers²  Lottie Skjöldebrand-Sparre⁴  Frida Hosseini⁴  Helena Karypidis⁴  Michaela Granfors² 

[1] Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden;Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden;Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden;Department of Clinical Sciences, Division of Obstetrics and Gynaecology, Karolinska Institutet and Danderyd Hospital, Stockholm, Sweden

关键词: Thyroid;    Single nucleotide polymorphism;    Recurrent miscarriage;    Phosphodiesterase 8B;   

Others  :  1177758
DOI  :  10.1186/1471-2350-13-121

 received in 2012-04-19, accepted in 2012-12-10,  发布年份 2012

【 摘 要 】

Background

Recurrent miscarriage affects approximately 1% of all couples. There is a known relation between hypothyroidism and recurrent miscarriage. Phosphodiesterase 8B (PDE8B) is a regulator of cyclic adenosine monophosphate (cAMP) with important influence on human thyroid metabolism. Single nucleotide polymorphism (SNP) rs 4704397 in the PDE8B gene has been shown to be associated with variations in serum Thyroid Stimulating Hormone (TSH) and thyroxine (T4) levels. The aim of this study was to investigate whether there is an association between the SNP rs 4704397 in the PDE8B gene and recurrent miscarriage.

Methods

The study was designed as a retrospective case control study. 188 cases with recurrent miscarriage were included and compared with 391 controls who had delivered at least once and with no history of miscarriage or assisted reproduction.

Results

No difference between cases and controls concerning age was found. Bivariate associations between homozygous A/A (OR 1.57, 95% CI 0.98-2.52) as well as G/G carriers (OR 1.52, 95% CI 1.02-2.25) of SNP rs 4704397 in PDE8B and recurrent miscarriage were verified (test for trend across all 3 genotypes, p = 0.059). After adjustment for known confounders such as age, BMI and smoking the association between homozygous A/A (AOR 1.63, 95% CI 1.01 - 2.64, p = 0.045) and G/G (AOR 1.52, 95% CI 1.02 - 2.27, p = 0.039) carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage remained.

Conclusions

Our findings suggest that there is an association between homozygous A/A as well as homozygous G/G carriers of SNP rs 4704397 in PDE8B and recurrent miscarriage.

【 授权许可】

   
2012 Granfors et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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