Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys

BMC Nephrology

Herbert Y. Lin²  Ravi I. Thadhani²  Julia Wenger²  Jodie L. Babitt²  Winfred W. Williams²  Sarah Dougherty²  Caitlin A. Trottier²  Dorothy A. Sullivan²  Arash Anvari¹  Manish Dhyani¹  Qingli Zhu¹  Andrew S. Allegretti²  Anthony E. Samir¹ 

[1]Department of Radiology, Massachusetts General Hospital, Boston 02114, MA, USA

[2]Department of Medicine, Division of Nephrology, Massachusetts General Hospital, 185 Cambridge St, Suite 8.216, Boston 02114, MA, USA

关键词: Ultrasound;    Shear wave elastography;    Fibrosis;    Stiffness;    Chronic kidney disease;   

Others  :  1222305
DOI  :  10.1186/s12882-015-0120-7

 received in 2015-02-05, accepted in 2015-07-22,  发布年份 2015

【 摘 要 】

Background

There currently is a need for a non-invasive measure of renal fibrosis. We aim to explore whether shear wave elastography (SWE)-derived estimates of tissue stiffness may serve as a non-invasive biomarker that can distinguish normal and abnormal renal parenchymal tissue.

Methods

Participants with CKD (by estimated GFR) and healthy volunteers underwent SWE. Renal elasticity was estimated as Young’s modulus (YM) in kilopascals (kPa). Univariate Wilcoxon rank-sum tests were used.

Results

Twenty-five participants with CKD (median GFR 38 mL/min; quartile 1, quartile 3 28, 42) and 20 healthy controls without CKD underwent SWE performed by a single radiologist. CKD was associated with increased median YM (9.40 [5.55, 22.35] vs. 4.40 [3.68, 5.70] kPa; p = 0.002) and higher median intra-subject inter-measurement estimated YM’s variability (4.27 [2.89, 9.90] vs. 1.51 [1.21, 2.05] kPa; p < 0.001).

Conclusions

SWE-derived estimates of renal stiffness and intra-subject estimated stiffness variability are higher in patients with CKD than in healthy controls. Renal fibrosis is a plausible explanation for the observed difference in YM. Further studies are required to determine the relationship between YM, estimated renal stiffness, and renal fibrosis severity.

【 授权许可】

   
2015 Samir et al.

【 图 表 】

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