Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma

BMC Clinical Pathology

Elin Hadler-Olsen³  Lars Uhlin-Hansen¹  Sonja E Steigen¹  Oddveig G Rikardsen²  Anna M Wirsing³ 

[1] Diagnostic Clinic – Clinical Pathology, University Hospital of North Norway, Tromsø 9038, Norway;Department of Otorhinolaryngology, University Hospital of North Norway, Tromsø 9038, Norway;Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø 9037, Norway

关键词: Germinal centre;    Follicular dendritic cell;    High-endothelial venule;    B-cell;    Tertiary lymphoid structure;    Prognostic factor;    Oral squamous cell carcinoma;   

Others  :  1084503
DOI  :  10.1186/1472-6890-14-38

 received in 2014-03-31, accepted in 2014-08-18,  发布年份 2014

【 摘 要 】

Background

Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate the incidence of tertiary lymphoid structures in oral squamous cell carcinomas, and if present, analyse whether they were associated with clinical outcome.

Methods

Tumour samples from 80 patients with oral squamous cell carcinoma were immunohistochemically stained for B-cells, follicular dendritic cells, T-cells, germinal centre B-cells and high-endothelial venules. Some samples were sectioned at multiple levels to assess whether the presence of tertiary lymphoid structures varied within the tumour.

Results

Tumour-associated tertiary lymphoid structures were detected in 21 % of the tumours and were associated with lower disease-specific death. The presence of tertiary lymphoid structures varied within different levels of a tissue block.

Conclusions

Tertiary lymphoid structure formation was found to be a positive prognostic factor for patients with oral squamous cell carcinoma. Increased knowledge about tertiary lymphoid structure formation in oral squamous cell carcinoma might help to develop and guide immune-modulatory cancer treatments.

【 授权许可】

   
2014 Wirsing et al.; licensee BioMed Central Ltd.

【 图 表 】

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