The value of pancreatic stone protein in predicting acute appendicitis in patients presenting at the emergency department with abdominal pain

BMC Gastroenterology

Rolf Graf¹  Stefan Breitenstein¹  Christian Eugen Oberkofler¹  Thomas Bächler¹  Përparim Limani¹  Dimitri Aristotle Raptis¹  Christoph Tschuor¹ 

[1] Department of Surgery, University Hospital Zurich, Raemistrasse 100, Zurich, CH-8091, Switzerland

关键词: Abdominal pain;    Acute appendicitis;    Pancreatic stone protein;    PSP;   

Others  :  858314
DOI  :  10.1186/1471-230X-12-154

 received in 2012-09-24, accepted in 2012-10-12,  发布年份 2012

【 摘 要 】

Background

Pancreatic Stone Protein (PSP) is a protein naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that blood PSP levels rise in the presence of inflammation or infection. However, it is not known whether PSP is superior to other established blood tests (e.g. White Blood Count, Neutrophils or C - reactive protein) in predicting appendicitis in patients presenting with abdominal pain and a clinical suspicion of appendicitis at the emergency room.

Methods/design

The PSP Appendix Trial is a prospective, multi-center, cohort study to assess the value of PSP in the diagnostic workup of acute appendicitis. 245 patients will be prospectively recruited. Interim analysis will be performed once 123 patients are recruited. The primary endpoint of the study concerns the diagnostic accuracy of PSP in predicting acute appendicitis and therefore the evidence of appendicitis on the histopathological specimen after appendectomy.

Discussion

The PSP Appendix Trial is a prospective, multi-center, cohort study to assess the value of PSP in the diagnostic workup of acute appendicitis.

Trial registration

ClinicalTrials.gov: NCT01610193; Institution Ethical Board Approval ID: KEKZH- Nr. 2011–0501

【 授权许可】

   
2012 Tschuor et al.; licensee BioMed Central Ltd.

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