BMC Nephrology | |
Case report: anti-glomerular basement membrane antibody disease with normal renal function | |
Yoshiyuki Kuroyanagi1  Katuaki Kasahara1  Yoshimitu Goto1  China Nagano1  | |
[1] Japanese Red Cross Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya City 466-8650, Aichi Prefecture, Japan | |
关键词: case report; School urine screening program; Normal renal function; Pediatrics; Anti-GBM; | |
Others : 1231058 DOI : 10.1186/s12882-015-0179-1 |
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received in 2015-06-15, accepted in 2015-10-29, 发布年份 2015 | |
【 摘 要 】
Background
Anti-glomerular basement membrane (GBM) antibody disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis caused by autoantibodies against the α3-chain of type IV collagen in the GBM.
Case presentation
An 8-year-old girl with hematuria and proteinuria due to anti-GBM nephritis was diagnosed with hematuria and proteinuria during a school urine screening program. Her blood pressure and serum creatinine levels were normal. Her hematuria and proteinuria persisted for several months. Since a spot urine protein to creatinine ratio was around 7 g/g Cre, a percutaneous renal biopsy was performed. Immnofluorescent staining demonstrated a linear pattern for immunoglobulin G along the entire GBM. Chest computed tomography was normal. Anti-GBM antibody assays were reported as slightly raised; thus, the diagnosis was anti-GBM disease with normal renal function. Treatment included plasma exchange, intravenous high-dose methylprednisolone, and cyclophosphamide as a mainstay medication. The treatment was rapidly effective with an immediate decrease in anti-GBM titers and proteinuria.
Conclusions
Cases of anti-GBM disease with normal renal function in children are rare. Treatment in children has not been established; therefore, clinicians need to carefully select an effective treatment because the prognosis is poor.
【 授权许可】
2015 Nagano et al.
【 预 览 】
Files | Size | Format | View |
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20151109024550806.pdf | 2447KB | download | |
Fig. 1. | 91KB | Image | download |
【 图 表 】
Fig. 1.
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