Neoadjuvant chemotherapy in well-differentiated fetal adenocarcinoma: a case report

BMC Research Notes

Hassan Errihani³  Abdellatif Benosman¹  Fahd Ouchen¹  Meriem Aitelhaj³  Nabil Ismaili²  Saber Boutayeb³  Sihame Lkhoyaali³ 

[1] Department of thoracic surgery, Hospital Avicenne, Rabat, Morocco;Department of Medical Oncolgy, Marrakech, Morocco;Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco

关键词: Prognosis;    Chemotherapy;    Well-differentiated fetal adenocarcinoma;   

Others  :  1132812
DOI  :  10.1186/1756-0500-7-283

 received in 2013-09-15, accepted in 2014-04-28,  发布年份 2014

【 摘 要 】

Background

Fetal adenocarcinoma of the lung is a rare subtype of pulmonary adenocarcinoma with a relative estimated incidence of 0.5% or fewer of all lung cancers. Because of its extreme rarity, there have been no controlled clinical trials investigating treatment regimens for fetal adenocarcinoma and, as a result, there are no guidelines for management.

Case presentation

We report a case of a well-differentiated fetal adenocarcinoma, which is a variant of pulmonary blastoma, that is a low-grade malignancy and associated with a good prognosis. A 29-year-old Moroccan man presented with a well-differentiated fetal adenocarcinoma staged T3N0M0, who received 3 cycles of neoadjuvant chemotherapy followed by surgery, with no recurrence at 2 years follow-up.

Conclusion

Fetal adenocarcinoma is a rare suptype of adenocarcinoma. Surgical resection is the treatment of choice for resectable disease. The role of chemotherapy in the neoadjuvant setting or adjuvant setting is not well defined.

【 授权许可】

   
2014 Lkhoyaali et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

【 参考文献 】

• [1]Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, et al.: International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011, 6:244-285.
• [2]Thompson RJ, Hasleton PS, Taylor PM, Woodhead M, Byrd LM: Haemoptysis in pregnancy caused by a well-differentiated fetal adenocarcinoma: a case report. J Med Case Reports 2010, 4:17. BioMed Central Full Text
• [3]Luo DL, Liu YH, Zhuang HG, Liao RQ, Luo XL, Xu FP, Zhang F: Clinicopathologic study of pulmonary adenocarcinoma with features of bronchioloalveolar carcinoma. Zhonghua Bing Li Xue Za Zhi 2008, 37(11):737-742.
• [4]Esper A, Force S, Gal A, Wolfenden LL: A 36-year-old woman with hemoptysis and a lung mass 3 months after delivery. Chest 2006, 130(5):1620-1623.
• [5]Cutler CS, Michel RP, Yassa M, Langleben A: Pulmonary blastoma: case report of a patient with a 7-year remission and review of chemotherapy experience in the world literature. Cancer 1998, 82(3):462-467.
• [6]Fujino S, Asada Y, Konishi T, Asakura S, Kato H, Mori A: Well-differentiated fetal adenocarcinoma of lung. Lung Cancer 1995, 13(3):311-316.
• [7]Matsuoka T, Sugi K, Matsuda E, Umemori Y, Okabe K, Hirasawa K, Azuma T: Clear cell adenocarcinoma with acomponent of well-differentiated fetal adenocareinoma; report of a case. Kyobu Geka 2006, 59(9):867-870.
• [8]Kradin RL, Young RH, GR DI c, Kirkham SE, Mark EJ: Pulmonary blastoma with agyrophil cells and lacking sarcomatous features(pulmonary endodermal tumor resembling fetal lung). Am J Surg Pathol 1982, 6:165-172.
• [9]Sheehan KM, Curran J, Kay EW, Broe P, Grace A: Well differentiated fetal adenocarcinoma of the lung in a 29-year-old woman. J Clin Pathol 2003, 56:478-479.
• [10]Politiek MJ, Vrugt B, Aalbers R: A 49-year-old woman with well differentiated fetal adenocarcinoma. The Netherlands J Med 2001, 58:177-180.
• [11]Koss MN, Hochholzer L, O’Leary T: Pulmonary blastomas. Cancer 1991, 67(9):2368-2381.
• [12]Sato S, Koike T, Yamato Y, Yoshiya K, Honma K, Tsukada H: Resected well-differentiated fetal pulmonary adenocarcnioma and summary of 25 cases reported in Japan. Jpn J Thorac Cardiovasc Surg 2006, 54:539-542.
• [13]Van Loo S, Boeykens E, Stappaerts I, Rutsaert R: Classic biphasic pulmonary blastoma: a case report and review of the literature. Lung Cancer 2011, 73:127-132.
• [14]Zaidi A, Zamvar V, Macbeth F, Gibbs AR, Kulatilake N, Butchart EG: Pulmonary blastoma: medium-term results from a regional center. Ann Thorac Surg 2002, 73:1572-1575.
• [15]Chanhee K, Sang Y, Beom JL, Jung-Joon C, Hyung JK, Chul Min A, Heejin P, Eun NC, Yoon Soo C: A case of locally advanced well-differentiated fetal adenocarcinoma of the lung treated with concurrent chemoradiation therapy. Tuberc Respir Dis 2013, 74(5):226-223.