Analysis of risk factors of ST-segment elevation myocardial infarction in young patients

BMC Cardiovascular Disorders

JinFang Li²  Peng Wenjin¹  Li Xin¹  Hu Xiaomin¹  Wang Yu¹  Liu Bojiang¹  Liu Yingwu¹  Li Tong¹  Wang Yunyun¹ 

[1]Cardiac Center, Third Central Hospital of Tian Jin, Tian Jin 300170, China

[2]Essen Medical Associates, P.C.2015 Grand concourse, Bronx, NY 10453, USA

关键词: Young patients;    ST-segment elevation myocardial infarction;    Risk factors;    Glycated hemoglobin;    Fibrinogen;    Antecedent angina pectoris;   

Others  :  1088416
DOI  :  10.1186/1471-2261-14-179

 received in 2014-02-22, accepted in 2014-12-01,  发布年份 2014

【 摘 要 】

Background

Acute myocardial infarction (AMI) is often present in old populations and rare in young people. Its incidence significantly increased recent years. The mechanism and disease course of AMI in young people are probably different from that in old population. The aim of this study was to analyze clinical risk factors of STEMI in young patients.

Methods

Data was collected from consecutive patients ≤ 44 years of age (young; n = 86) and 60–74 years of age (old; n = 65) diagnosed with STEMI, and 79 young age-matched patients without coronary artery disease (CAD), hospitalized between January 2009 and June 2013.

Results

The young STEMI group had a significantly higher proportion of males (88.37 vs. 53.16%; P < 0.01), smokers (82.56 vs. 49.37%; P < 0.01) and patients with a family history of early CAD (54.65 vs. 32.91%; P < 0.05) than age-matched controls. Young STEMI patients also had significantly higher levels of fasting blood sugar (6.39 vs. 5.25 mmol/L; P < 0.001), glycated hemoglobin (HbA1c) (6.26 vs. 5.45%; P < 0.05), total cholesterol (5.14 vs. 4.65 mmol/L, P < 0.05), and fibrinogen (Fib) (3.39 vs. 2.87; P < 0.01). Compared with the old STEMI group, young STEMI patients had significantly higher proportions of males (88.37 vs. 63.08%; P < 0.01) smokers (82.56 vs. 41.54%; P < 0.01), and those with a family history of early CAD (54.65 vs. 18.46%; P < 0.01). Young STEMI patients also lower Fib (3.39 vs. 3.88 g/L; P < 0.01), less frequent occurrence of angina pectoris before STEMI (13.95 vs. 29.23%; P < 0.05) compared with the old STEMI group. Logistic regression analysis indicated that male sex (OR = 5.891), smoking (OR = 3.500), family history of early CAD (OR = 3.194), Fib (OR = 2.414) and HbA1c (OR = 1.515) are associated with STEMI in young patients.

Conclusion

In addition to previously recognized risk factors (male sex, smoking and family history of early CAD), Fib and HbA1c are associated with STEMI in individuals ≤ 44 years of age without antecedent angina pectoris.

【 授权许可】

   
2014 Yunyun et al.; licensee BioMed Central Ltd.

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