Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease

BMC Medical Genetics

Iftikhar J Kullo¹  Keyue Ding¹ 

[1] Division of Cardiovascular Diseases, Mayo Clinic, Rochester MN 55905, USA

关键词: population differentiation;    risk allele frequency;    genome-wide association study;    genetics;    cardiovascular disease;   

Others  :  1178055
DOI  :  10.1186/1471-2350-12-55

 received in 2010-09-23, accepted in 2011-04-20,  发布年份 2011

【 摘 要 】

Background

We hypothesized that the frequencies of risk alleles of SNPs mediating susceptibility to cardiovascular diseases differ among populations of varying geographic origin and that population-specific selection has operated on some of these variants.

Methods

From the database of genome-wide association studies (GWAS), we selected 36 cardiovascular phenotypes including coronary heart disease, hypertension, and stroke, as well as related quantitative traits (eg, body mass index and plasma lipid levels). We identified 292 SNPs in 270 genes associated with a disease or trait at P < 5 × 10^-8. As part of the Human Genome-Diversity Project (HGDP), 158 (54.1%) of these SNPs have been genotyped in 938 individuals belonging to 52 populations from seven geographic areas. A measure of population differentiation, F_ST, was calculated to quantify differences in risk allele frequencies (RAFs) among populations and geographic areas.

Results

Large differences in RAFs were noted in populations of Africa, East Asia, America and Oceania, when compared with other geographic regions. The mean global F_ST (0.1042) for 158 SNPs among the populations was not significantly higher than the mean global F_ST of 158 autosomal SNPs randomly sampled from the HGDP database. Significantly higher global F_ST (P < 0.05) was noted in eight SNPs, based on an empirical distribution of global F_ST of 2036 putatively neutral SNPs. For four of these SNPs, additional evidence of selection was noted based on the integrated Haplotype Score.

Conclusion

Large differences in RAFs for a set of common SNPs that influence risk of cardiovascular disease were noted between the major world populations. Pairwise comparisons revealed RAF differences for at least eight SNPs that might be due to population-specific selection or demographic factors. These findings are relevant to a better understanding of geographic variation in the prevalence of cardiovascular disease.

【 授权许可】

   
2011 Ding and Kullo; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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