Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis

BMC Nephrology

Marcellus Henrique Loiola Ponte de Souza²  Armênio Aguiar dos Santos²  Paulo Roberto Santos¹  Luiz Derwal Salles Junior¹ 

[1] Sobral School of Medicine, Federal University of Ceará, Avenida Comandante Maurocélio Rocha Ponte, 100 - CEP 62.042-280, Sobral, CE, Brazil;Department of Physiology and Pharmacology, Federal University of Ceará, Rua Coronel Nunes de Melo, 1127 – CEP 60.431-970, Fortaleza, CE, Brazil

关键词: Delayed gastric emptying;    Gastric motility;    Dyspepsia;    Hemodialysis;    End-stage renal disease;   

Others  :  1082764
DOI  :  10.1186/1471-2369-14-275

 received in 2013-08-18, accepted in 2013-12-11,  发布年份 2013

【 摘 要 】

Background

Dyspepsia is common among end-stage renal disease (ESRD) patients and its association with delayed gastric emptying is not well established. We assessed the association of dyspepsia with gastric emptying time in ESRD patients undergoing hemodialysis (HD).

Methods

Dyspepsia was assessed through the Porto Alegre Dyspeptic Symptoms Questionnaire (PADYQ). PADYQ’s scores ≥ 6 classified participants as dyspeptic. The octanoic acid breath test using ¹³carbon was employed to assess the gastric emptying time. Based on the test, time in minutes to metabolize the first half of the ¹³carbon in the test meal (t1/2) was calculated. Association of dyspepsia with gastric emptying time was tested by the correlation between PADYQ scores and t1/2, and also by comparing t1/2 between dyspeptics and non-dyspeptics.

Results

There were 34 (68.0%) dyspeptic patients. Dyspepsia score was positively correlated with t1/2 (r = 0.366; p = 0.009). Dyspeptics had longer t1/2 compared to non-dyspeptics, respectively, 238.0 ± 92.9 versus 185.5 ± 45.5 minutes (p = 0.042).

Conclusions

Delayed gastric emptying was associated with dyspepsia. Prokinetic medications could have a role in preventing or relieving dyspeptic symptoms among HD patients. Future research in larger samples is necessary to confirm this association.

【 授权许可】

   
2013 Salles Junior et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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