Long-term Proton Pump Inhibitors induces recurrent Urinary Tract Infections: A case study

2nd International Conference on Natural Resources and Life Sciences

生态环境科学

Cokro, F.^1 ; Arrang, S.T.^1

Department of Pharmacy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, North Jakarta

14440, Indonesia^1

关键词: Dyspepsia;    esomeprazole;    hypomagnesemia;    Pantoprazole;    Patient prognosis;    Proton pump inhibitors;    Urinary tract infections;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/293/1/012017/pdf
DOI  :  10.1088/1755-1315/293/1/012017

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

A 28 y.o. woman with dyspepsia had been taking proton pump inhibitor (PPI) for about seven months. After that, she experienced recurrent urinary tract infections (UTI), which she never experienced before. There was three episodes of UTI requiring antibiotic occurred, those are in January 2017, February 2017, and May 2017. During those episodes, she took once to twice daily dose of PPI regularly due to dyspepsia which she had experienced since July 2016. After stopping the PPI medication in August 2017, she had no single episodes of UTI (until June 2018). Based on patient prognosis in this case, there might be possibility that the patient developed recurrent UTI after long-term use of PPI. The mechanism is unclear but it seems that PPI induced hypomagnesemia, and then influences immune system, causing urinary tract infections.