Ethnic differences in the association between blood pressure components and chronic kidney disease in middle aged and older Asian adults

BMC Nephrology

Tien Yin Wong¹  Tazeen H Jafar³  E Shyong Tai²  Boon Wee Teo²  Charumathi Sabanayagam¹ 

[1] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Program in Health Services & Systems Research, Duke-NUS Graduate Medical School, Singapore, Singapore

关键词: Singapore;    Glomerular filtration rate;    Chronic kidney disease;    Blood pressure;    Asians;   

Others  :  1082952
DOI  :  10.1186/1471-2369-14-86

 received in 2012-11-29, accepted in 2013-04-07,  发布年份 2013

【 摘 要 】

Background

Chronic kidney disease (CKD) is an emerging public health problem worldwide. Previous studies have shown an association between blood pressure (BP) and CKD. However, it is not clear if there are ethnic differences in this association. We examined the association between BP and CKD in a multi-ethnic Asian population in Singapore.

Methods

We analysed data from three large population-based studies conducted between 2004–2011, (n=3,167 Chinese, 3,082 Malays and 3,228 Indians) aged 40–80 years. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73m² from serum creatinine. Hypertension was defined as a self-reported current use of antihypertensive medication or systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg. We also analysed the association of CKD with individual BP components.

Results

The prevalence of both hypertension and CKD was higher among Malays (68.6, 21%) compared to Chinese (57.9, 5.9%) and Indians (56.0, 7.4%), but treatment for hypertension was lower among Malays (53.4%) compared to Chinese (89.8%) and Indians (83.1%). Hypertension was associated with CKD in all three ethnic groups (OR [95% CI] = 2.71 [1.59-4.63], 2.08 [1.62-2.68], 2.43 [1.66-3.57] in Chinese, Malays and Indians). Among the BP components, both systolic and diastolic BP were associated with CKD in Malays whereas, systolic BP was not significantly associated with CKD, and diastolic BP showed an inverse association which was explained by anti-hypertensive medication use in Chinese and Indians.

Conclusions

Hypertension was associated with CKD in Chinese, Malays and Indians. However, the BP components were associated with CKD only in Malays.

【 授权许可】

   
2013 Sabanayagam et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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