BMC Oral Health | |
Oral health status of patients with acute coronary syndrome – a case control study | |
Rainer F Mausberg1  Else Hornecker1  Hans-Joachim Helms2  Gerd Hasenfuß3  Andrea Priegnitz1  Dirk Ziebolz1  | |
[1] Department of Preventive Dentistry, Periodontology and Cariology, University Medical Centre Goettingen, Goettingen, Germany;Department of Medical Statistics, University Medical Centre Goettingen, Goettingen, Germany;Department of Cardiology and Pneumology, University Medical Centre Goettingen, Goettingen, Germany | |
关键词: Unstable angina pectoris; Acute myocardial infarction; Acute coronary syndrome; Periodontitis; Gingival inflammation; Oral hygiene; Oral health; | |
Others : 1126491 DOI : 10.1186/1472-6831-12-17 |
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received in 2011-08-17, accepted in 2012-06-22, 发布年份 2012 | |
【 摘 要 】
Background
The aim of this investigation was to assess the state of oral health of patients with acute coronary syndrome (ACS) and to compare this with that of a provably healthy control group (H).
Methods
33 patients who were receiving treatment as inpatients following acute myocardial infarction or unstable angina pectoris took part in the study (ACS-group). A healthy control group (H-group) made up of blood donors, was formed following matching for age, gender, and smoking habit with the study patient group.
The dental investigation consisted of the dental status (DMF-T), a plaque-Index (PI), an assessment of gingival inflammation (GI) and periodontal situation (Periodontal Screening Index: PSR®/PSI), and attachment loss (AL). Statistical evaluation: t-test, Mann–Whitney-test and chi- squared test (level of significance p < 0.05).
Results
The mean DMF-T of the ACS-group (18.7 ± 6.8) and the H-group (19.4 ± 5.1) showed no difference (p = 0.7). Although, in the ACS-group the average loss of teeth (M-T: 8.4 ± 5.2) was higher than in the H-group (M-T: 5.8 ± 6.6) the difference was not significant (p = 0.2). Whereas with the PI no difference between the two groups was found (p = 0.9), the ACS-group showed significantly more signs of inflammation (GI) than the H-group (p = 0.045). In the case of PSR®/PSI, there was no difference between the two groups (p = 0.7). With regard to AL, no difference was revealed between ACS- and H-group (p = 0.2).
Conclusion
Although, the state of oral health of the ACS-group differed only insignificantly from that of control, patients with ACS showed more signs of gingival inflammation and a higher loss of teeth.
【 授权许可】
2012 Ziebolz et al.;licensee BioMed Central Ltd.
【 预 览 】
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20150218160624891.pdf | 236KB | download |
【 参考文献 】
- [1]The Eurorean Society of Cardiology - Guidelines: Management of the stable angina pectoris. Eur Heart J 1997, 18:394-413.
- [2]Tunstall-Pedoe H, Kuulasmaa K, Mähönen M, Tolonen H, Ruokokoski E, Amouyel P: Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from the 37 WHO MONICA project populations. Lancet 1999, 353:1547-1557.
- [3]The European Society of Cardiology and the American College of Cardiology: Myocardial infarction redefined – A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction. Eur Heart J 2000, 21:1502-1513.
- [4]Fuster V, Badimon L, Badimon JJ, Chesebro JH: The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 1992, 326(4):242-250.
- [5]Fuster V, Badimon L, Badimon JJ, Chesebro JH: The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 1992, 326:310-318.
- [6]Greenland P, Knoll MD, Stamler J, Neaton JD, Dyer AR, Garside DB, Wilson PW: Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA 2003, 290:891-897.
- [7]Mattila KJ, Valtonen VV, Nieminen MS, Asikainen S: Role of infection as a risk factor for atherosclerosis, myocardial infarction, and stroke. Clin Infect Dis 1998, 26:719-734.
- [8]Kiechl S, Egger G, Mayr M, Wiedermann CJ, Bonora E, Oberhollenzer F, Muggeo M, Xu Q, Wick G, Poewe W, Willeit J: Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study. Circulation 2001, 103:1064-1070.
- [9]Kinane DF, Lowe GD: How periodontal disease may contribute to cardiovascular disease. Periodontol 2000 2000, 23:121-126.
- [10]Haffajee AD, Sokransky SS: Introduction to microbial aspects of periodontal biofilm communities, development and treatment. Periodontol 2000 2006, 42:7-12.
- [11]Page RC, Kornman KS: The pathogenesis of human periodontitis: an introduction. Periodontol 2000 1997, 14:9-11.
- [12]Heasman LSF, Preshaw PM, McCracken GI, et al.: The effect of smoking on periodontal treatment response: a review of clinical evidence. J Clin Periodontol 2006, 33(4):241-253.
- [13]Genco RJ, Ho AW, Grossi SG: Relationship of stress, Distress, and inadequate coping behaviors to periodontal disease. J Periodontol 1999, 70:711-723.
- [14]Mealey BL, Oates TW: Diabetes mellitus and periodontal diseases. J Periodontol 2006, 77:1289-1303.
- [15]Janket S, Baird AE, Chuang S, Jones JA: Meta analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003, 95:559-569.
- [16]Khader YS, Albashaireh ZS, Alomari MA: Periodontal diseases and the risk of coronary heart and cerebrovascular diseases: a meta-analysis. J Periodontol 2004, 75:1046-1053.
- [17]Bahekar AA, Singh S, Saha S, Molnar J, Arora R: The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J 2007, 154:830-837.
- [18]Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC: American Journal of Cardiology; Journal of Periodontology. The American Journal of Cardiology and Journal of Periodontology editors' consensus: periodontitis and atherosclerotic cardiovascular disease. J Periodontol 2009, 80:1021-1032.
- [19]Emingil G, Buduneli E, Aliyev A, Akilli A, Atilla G: Association between periodontal disease and acute myocardial infarction. J Periodontol 2000, 71:1882-1886.
- [20]Persson RG, Ohlsson O, Pettersson T, Renvert S: Chronic periodontitis, a significant relationship wih acute myocardial infarction. Eur Heart J 2003, 24:2108-2115.
- [21]Elter JR, Champagne CM, Offenbacher S, Beck JD: Relationship of periodontol disease and tooth loss to prevalence of coronary heart disease. J Periodontol 2004, 75:782-790.
- [22]Doĝan B, Buduneli E, Emingil G, Atilla G, Akilli A, Antinheimo J, Lakio L, Asikainen S: Characteristics of periodontal microflora in acute myocardial infarction. J Periodontol 2005, 76:740-748.
- [23]Blaizot A, Vergnes JN, Nuwwareh S, Amar J, Sixou M: Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J 2009, 59:197-209.
- [24]Stein JM, Kuch B, Conrads G, Fickl S, Chrobot J, Schulz S, Ocklenburg C, Smeets R: Clinical periodontal and microbiologic parameters in patients with acute myocardial infarction. J Periodontol 2009, 80:1581-1589.
- [25]Dorn JM, Genco RJ, Grossi SG, Falkner KL, Hovey KM, Iacoviello L, Trevisan M: Periodontal disease and recurrent cardiovascular events in survivors of myocardial infarction (MI): the Western New York Acute MI Study. J Periodontol 2010, 81:502-511.
- [26]Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA: Periodontal disease and coronary heart disease risk. JAMA 2000, 284:1406-1410.
- [27]Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA: Examining the link between coronary heart disease and the elimination of chronic dental infections. J Am Dent Assoc 2001, 132:883-889.
- [28]Howell TH, Ridker PM, Ajani UA, Hennekens CH, Christen WG: Periodontal disease and risk of subsequent cardiovascular disease in U.S. male physicians. J Am Coll Cardiol 2001, 37:445-450.
- [29]Hung HC, Joshipura KJ, Colditz G, Manson JE, Rimm EB, Speizer FE, Willett WC: The association between tooth loss and coronary heart disease in men and women. J Public Health Dent 2004, 64:209-215.
- [30]Hyman JJ, Winn DM, Reid BC: The role of cigarette smoking in the association between periodontal disease and coronary heart disease. J Periodontol 2002, 73:988-994.
- [31]Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA: Periodontitis-systemic disease associations in the presence of smoking--causal or coincidental? Periodontol 2000 2002, 30:51-60.
- [32]Micheelis W, Schiffner U: 4th German study on oral health (DMS IV). Institut der Deutschen Zahnärzte (Hrsg.); (IDZ Materialienreihe Band 31). Deutscher Zahnärzte Verlag DÄV, Köln; 2006. in German
- [33]Löe H, Silness J: Periodontal disease in pregnancy. I. Acta Odontol Scand 1963, 21:533-551.
- [34]Silness J, Löe H: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964, 22:121-136.
- [35]Ainamo J, Barmes D, Beagrie G, Cutress TW: Sardo- Infirri J. Development of the World Health Organization (WHO) Community Periodontal Index of Treatment Needs (CPITN). Int Dent J 1982, 32:281-291.
- [36]Diamanti-Kipioti A, Papapanou TN, Moraitaki-Zamitsai A, Lindhe J, Mitsis F: Comparative estimation of periodontal conditions by means of different index systems. J Clin Periodontol 1993, 20:656-661.
- [37]WHO. World Health Organization: Oral health surveys, basic methods. 4th edition. WHO; Oral Health Unit, Genf; 1997:1-40.
- [38]Cutress TW, Ainamo J, Sardo-Infirri J: The community periodontal index of treatment needs (CPITN) procedure for population groups and individuals. Int Dent J 1987, 37:222-223.
- [39]Lopez R, Oyarzun M, Naranjo C, Cumsille F, Ortiz M, Baelum V: Coronary heart disease and periodontitis - a case control study in Chilean adults. J Clin Periodontol 2002, 29:468-473.
- [40]Meurman JH, Qvarnström M, Janket S, Nuutinen P: Oral health and health behavior in patients referred for open-heart surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003, 95:300-307.
- [41]Willershausen B, Kasaj A, Willershausen I, Zahorka D, Briseño B, Blettner M, Genth-Zotz S, Münzel T: Association between chronic dental infection and acute myocardial infarction. J Endod 2009, 35:626-630.
- [42]Holmlund A, Holm G, Lind L: Number of Teeth as a Predictor of Cardiovascular Mortality in a Cohort of 7,674 Subjects Followed for 12 Years. J Periodontol 2010, 81:870-876.
- [43]Mattila KJ, Asikainen S, Wolf J, Jousimies-Somer H, Valtonen V, Nieminen M: Age, dental infections and coronary heart disease. J Dent Res 2000, 79:756-760.
- [44]Bazile A, Bissada NF, Nair R, Siegel BP: Periodontal assessment of patients undergoing angioplasty for treatment of coronary artery disease. J Periodontol 2002, 73:631-636.
- [45]Katz J, Chaushu G, Sharabi Y: On the association between hypercholesterolemia, cardiovacular disease and severe periodontal disease. J Clin Periodontol 2001, 28:865-868.
- [46]Spahr A, Klein E, Khuseyinova N, Boeckh C, Muche R, Kunze M, Rothenbacher D, Pezeshki G, Hoffmeister A, Koenig W: Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the coronary event and periodontal disease (CORODONT) study. Arch Intern Med 2006, 166:554-559.
- [47]Arbes SJ, Slade GD, Beck JD: Association between extent of periodontal attachment loss and self-reported history of heart attack: an analysis of NHANES III data. J Dent Res 1999, 78:1777-1782.