Rationale and design of South Asian Birth Cohort (START): a Canada-India collaborative study

BMC Public Health

Krishnamachari Srinivasan³  Koon K Teo²  Anura Kurpad³  Katherine Morrison²  Milan Gupta¹  Anil Vasudevan³  Sonia S Anand² 

[1] Canadian Cardiovascular Research Network, Brampton, Ontario;Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada;St John’s Research Institute and St. John’s Medical College, Bangalore, India

关键词: Canada;    India;    Early origins;    Insulin resistance;    Adiposity;    South Asian;    Birth cohort;   

Others  :  1162600
DOI  :  10.1186/1471-2458-13-79

 received in 2012-10-05, accepted in 2012-10-18,  发布年份 2013

【 摘 要 】

Background

People who originate from the Indian subcontinent (South Asians) suffer among the highest rates of type 2 diabetes in the world. Prior evidence suggests that metabolic risk factors develop early in life and are influenced by maternal and paternal behaviors, the intrauterine environment, and genetic factors. The South Asian Birth Cohort Study (START) will investigate the environmental and genetic basis of adiposity among 750 South Asian offspring recruited from highly divergent environments, namely, rural and urban India and urban Canada.

Methods

Detailed information on health behaviors including diet and physical activity, and blood samples for metabolic parameters and DNA are collected from pregnant women of South Asian ancestry who are free of significant chronic disease. They also undergo a provocative test to diagnose impaired glucose tolerance and gestational diabetes. At delivery, cord blood and newborn anthropometric indices (i.e. birth weight, length, head circumference and skin fold thickness) are collected. The mother and growing offspring are followed prospectively and information on the growth trajectory, adiposity and health behaviors will be collected annually up to age 3 years. Our aim is to recruit a minimum of 750 mother-infant pairs equally divided between three divergent environments: rural India, urban India, and Canada.

Summary

The START cohort will increase our understanding of the environmental and genetic determinants of adiposity and related metabolic abnormalities among South Asians living in India and Canada.

【 授权许可】

   
2013 Anand et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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