Surveillance for the prevention of chronic diseases through information association

BMC Medical Genomics

Alessandra Alaniz Macedo²  Maria da Graça Pimentel¹  Evandro Seron Ruiz²  José Augusto Baranauskas²  Juliana Tarossi Pollettini² 

[1] Department of Computer Science - ICMC - University of São Paulo, São Carlos-SP, Brazil;Department of Computer Science and Mathematics - FFCLRP - University of São Paulo (USP), Ribeirão Preto-SP, Brazil

关键词: Ontology;    Medical records and scientific papers;    Retrieval and application of biomedical knowledge and information;    Biomedical informatics;   

Others  :  797128
DOI  :  10.1186/1755-8794-7-7

 received in 2013-05-27, accepted in 2014-01-16,  发布年份 2014

【 摘 要 】

Background

Research on Genomic medicine has suggested that the exposure of patients to early life risk factors may induce the development of chronic diseases in adulthood, as the presence of premature risk factors can influence gene expression. The large number of scientific papers published in this research area makes it difficult for the healthcare professional to keep up with individual results and to establish association between them. Therefore, in our work we aim at building a computational system that will offer an innovative approach that alerts health professionals about human development problems such as cardiovascular disease, obesity and type 2 diabetes.

Methods

We built a computational system called Chronic Illness Surveillance System (CISS), which retrieves scientific studies that establish associations (conceptual relationships) between chronic diseases (cardiovascular diseases, diabetes and obesity) and the risk factors described on clinical records. To evaluate our approach, we submitted ten queries to CISS as well as to three other search engines (Google™, Google Scholar™ and Pubmed®;) — the queries were composed of terms and expressions from a list of risk factors provided by specialists.

Results

CISS retrieved a higher number of closely related (+) and somewhat related (+/-) documents, and a smaller number of unrelated (-) and almost unrelated (-/+) documents, in comparison with the three other systems. The results from the Friedman’s test carried out with the post-hoc Holm procedure (95% confidence) for our system (control) versus the results for the three other engines indicate that our system had the best performance in three of the categories (+), (-) and (+/-). This is an important result, since these are the most relevant categories for our users.

Conclusion

Our system should be able to assist researchers and health professionals in finding out relationships between potential risk factors and chronic diseases in scientific papers.

【 授权许可】

   
2014 Pollettini et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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