Stimulation frequency determines the distribution of language positive cortical regions during navigated transcranial magnetic brain stimulation

BMC Neuroscience

Sandro M Krieg³  Bernhard Meyer³  Florian Ringel³  Claus Zimmer¹  Stefanie Maurer³  Nico Sollmann³  Sebastian Ille³  Afra Wohlschlaeger¹  Monika Probst¹  Noriko Tanigawa²  Theresa Hauck³ 

[1] Section of Neuroradiology, Department of Radiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, Munich, 81675, Germany;Faculty of Linguistics, Philology, & Phonetics, University of Oxford, Walton Street, Oxford OX1 2HG, UK;Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, Munich, 81675, Germany

关键词: Verb generation;    Transcranial magnetic stimulation;    Pseudoword reading;    Object naming;    Navigated brain stimulation;    Mapping protocol;    Frequency;    Cortical mapping;    Action naming;   

Others  :  1135398
DOI  :  10.1186/s12868-015-0143-9

 received in 2014-11-11, accepted in 2015-02-11,  发布年份 2015

【 摘 要 】

Background

Although language mapping by repetitive navigated transcranial magnetic stimulation (rTMS) gains importance in neuropsychological research and clinical utility, neuroscientists still use different mapping protocols including different stimulation frequencies. To refine the existing language protocol, we tested two different repetition rates of 5 Hz/10 pulses and 7 Hz/10 pulses with a 0 ms delay in 19 healthy subjects. We furthermore investigated differences between both frequencies in case of performance of four different language tasks: object naming, pseudoword reading, verb generation, and action naming.

Results

Even the small variance in frequencies revealed statistically significant differences concerning the number and type of language errors. Stimulation with 5 Hz evoked a higher number of all occurred language errors in all language tasks (error rate object naming 14% (5 Hz) vs. 12% (7 Hz); pseudoword reading 4% (5 Hz) vs. 3% (7 Hz); verb generation 13% (5 Hz) vs. 11% (7 Hz); action naming 11% (5 Hz) vs. 9% (7 Hz)), whereas 7 Hz evoked specifically more total speech arrests.

Conclusion

These findings suggest that the stimulation frequency has to be adapted to the aim of the rTMS language investigation.

【 授权许可】

   
2015 Hauck et al.; licensee BioMed Central.

【 图 表 】

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