Combined effect of established BMI loci on obesity-related traits in an Algerian population sample

BMC Genetics

Louisa Goumidi⁵  Aline Meirhaeghe⁵  Leila Houti⁴  Philippe Amouyel⁵  Nadhira Saidi-Mehtar²  Imane Hamani-Medjaoui¹  Xavier Hermant⁵  Djabaria Naïma Meroufel²  Houssam Boulenouar²  Sarah Aicha Lardjam-Hetraf²  Hadjira Ouhaibi-Djellouli³  Sounnia Mediene-Benchekor³  Manel Nassima Badsi² 

[1] CNAS Hai Bouamama (El Hassi), Caisse Nationale des Assurances Sociales des travailleurs salariés, Clinique Spécialisée en Orthopédie et Rééducation des Victimes des Accidents de Travail, Oran, Algeria;Laboratoire de Génétique Moléculaire et Cellulaire, Université des Sciences et de Technologie d’Oran Mohamed Boudiaf, BP 1505 El M’Naouar, Oran, 31036, Algeria;Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université d’Oran, BP 1524. El M’Naouar, Oran, 31000, Algeria;LABoratoire des Systèmes d’Information en Santé, Université d’Oran, Oran, 31000, Algeria;INSERM, U744; Institut Pasteur de Lille, Université Lille Nord de France, 1 rue du Pr. Calmette, Lille Cedex, France

关键词: ISOR study;    Algerian population;    Obesity;    BMI;    Polymorphism;    Genetic predisposition score;   

Others  :  1085207
DOI  :  10.1186/s12863-014-0128-1

 received in 2014-06-02, accepted in 2014-11-06,  发布年份 2014

【 摘 要 】

Background

Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study.

The ISOR study of 787 adult subjects (aged between 30 and 64) provided a representative sample of the population living in the city of Oran (north-west of Algeria). We investigated the combined effect of 29 BMI established genetic variants using a genetic predisposition score (GPS) on anthropometric traits and obesity risk in 740 subjects.

Results

We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m² (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004).

Conclusions

Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.

【 授权许可】

   
2014 Badsi et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Kopelman P: Health risks associated with overweight and obesity. Obes Rev 2007, 8:13-17.
• [2]Bloomgarden ZT: American Diabetes Association Annual Meeting, 1999: diabetes and obesity. Diabetes Care 2000, 23:118-124.
• [3]Yancey AK, McCarthy WJ, Taylor WC, Merlo A, Gewa C, Weber MD, Fielding JE: The Los Angeles Lift Off: a sociocultural environmental change intervention to integrate physical activity into the workplace. Prev Med 2004, 38:848-856.
• [4]World health statistics. 2012.
• [5]Flegal KM, Carroll MD, Ogden CL, Johnson CL: Prevalence and trends in obesity among US adults, 1999–2000. JAMA 2002, 288:1723-1727.
• [6]Shields M: Nutrition: Findings from the Canadian Community Health Survey – Overweight Canadian children and adolescents.Component of Statistics Canada Catalogue 2005, no.82–620-MWE2005001.
• [7]Berghöfer A, Pischon T, Reinhold T, Apovian CM, Sharma AM, Willich SN: Obesity prevalence from a European perspective: a systematic review. BMC Public Health 2008, 8:200. BioMed Central Full Text
• [8]El Rhazi K, Nejjari C, Zidouh A, Bakkali R, Berraho M, Barberger-Gateau P: Prevalence of obesity and associated sociodemographic and lifestyle factors in Morocco. Public Health Nutr 2010, 14:160-167.
• [9]El Ati J, Traissac P, Delpeuch F, Aounallah-Skhiri H, Beji C, Eymard-Duvernay S, Bougatef S, Kolsteren P, Maire B, Ben Romdhane H: Gender Obesity Inequities Are Huge but Differ Greatly According to Environment and Socio-Economics in a North African Setting: A National Cross-Sectional Study in Tunisia. PLoS One 2012, 7:e48153.
• [10]Atek M, Laid Y, Mezimeche N, Boutekdjiret L, Lebcir H: L’Obésité chez l’adulte de 35 à 70 ans en Algérie. Projet TAHINA.Institut national de santé publique Alger Algérie 2010, 1–93.
• [11]Levitt NS: Diabetes in Africa: epidemiology, management and healthcare challenges. Heart 2008, 94:1376-1382.
• [12]Atwood LD, Heard-costa NL, Cupples LA, Jaquish CE, Wilson PWF, D’Agostino RB: Genome wide linkage analysis of body mass index across 28 years of the Framingham Heart Study. Am J Hum Genet 2002, 71:1044-1050.
• [13]Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Sian E, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJF, Barroso I, Wareham NJ, et al.: A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity. Science 2007, 316:889-894.
• [14]Loos RJF, Lindgren CM, Li S, Wheeler E, Hua J, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney ASF, Elliott KS, Elliott P, Evans DM, Farooqi IS, et al.: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008, 40:768-775.
• [15]Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek ALM, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, et al.: Genome-wide association yield new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009, 41:18-24.
• [16]Willer CJ, Speliotes EK, Loos RJF, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, et al.: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009, 41:25-34.
• [17]Heard-Costa LN, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, Aspelund T, Eiriksdottir G, Garcia M, Launer LJ, Smith AV, Mitchell BD, McArdle PF, Shuldiner AR, Bielinski SJ, Boerwinkle E, Brancati F, Demerath EW, Pankow JS, Arnold AM, Chen YI, Glazer NL, McKnight B, Psaty BM, Rotter JI, Amin N, Campbell H, Gyllensten U, et al.: NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 2009, 5:e1000539.
• [18]Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, et al.: Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet 2009, 5:e1000508.
• [19]Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango AH, Lindgren CM, Luan J, Magi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segre AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpelainen TO, et al.: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010, 42:937-948.
• [20]Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, et al.: Replicating genotype-phenotype associations. Nature 2007, 447:655-660.
• [21]Loos RJ: Genetic determinants of common obesity and their value in prediction. Best Pract Res Clin Endocrinol Metab 2012, 26:211-226.
• [22]Bouhaha R, Baroudi T, Ennafaa H, Emanuel V, Hafawa A, Sassi R, Vatin V, Froguel P, Benammar-el Gaaied A, Meyre D, Vaxillaire M: Study of TNFalpha -308G/A and IL6–174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. Clin Biochem 2010, 43:549-552.
• [23]Bouhaha R, Choquet H, Meyre D, Abid Kamoun H, Ennafaa H, Baroudi T, Sassi R, Vaxillaire M, Elgaaied A, Froguel P, Cauchi S: TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia. Pathol Biol (Paris) 2010, 58:426-429.
• [24]Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ouedrani A, Ben Rejeb N, Rebhi L, Ouedrani A, Ben Rejeb N, Nabli N, Ben Abdelaziz A, Bouslama A: Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Genet Test Mol Biomarkers 2012, 16:726-733.
• [25]Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ben Rejeb N, Nabli N, Ben Abdelaziz A, Bouslama A: Association between four resistin polymorphisms, obesity, and metabolic syndrome parameters in tunisian volunteers. Genet Test Mol Biomarkers 2012, 16:1356-1362.
• [26]El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M: Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population. Diabetes Metab 2009, 35:37-42.
• [27]Boulenouar H, Mediene Benchekor S, Meroufel DN, Lardjam Hetraf SA, Ouhaibi Djellouli H, Hermant X, Grenier-Boley B, Hamani Medjaoui I, Saidi Mehtar N, Amouyel P, Houti L, Meirhaeghe A, Goumidi L: Impact of APOE gene polymorphisms on the lipid profile in an Algerian population. Lipids Health Dis 2013, 12:155. BioMed Central Full Text
• [28]Qi Q, Chu AY, Kang JH, Jensen MK, Curhan GC, Pasquale LR, Ridker PM, Hunter DJ, Willett WC, Rimm EB, Chasman DI, Hu FB, Qi L: Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 2012, 367:1387-1396.
• [29]Charles MA, Eschwege E, Basdevant A: Monitoring the obesity epidemic in France. The Obepi surveys 1997–2006. Obesity 2008, 16:2182-2186.
• [30]Rodríguez-Rodríguez E, López-Plaza B, López-Sobaler AM, Ortega RM: Overweight and obesity among Spanish adults. Nutr Hosp 2011, 26:355-363.
• [31]Gallus S, Colombo P, Scarpino V, Zuccaro P, Negri E, Apolone G, La Vecchia C: Overweight and obesity in Italian adults 2004, and an overview of trends since 1983. Eur J Clin Nutr 2006, 60:1174-1179.
• [32]Diet, Physical Activity and Obesity Statistics. 2006.
• [33]Wahab KW, Sani MU, Yusuf BO, Gbadamosi M, Gbadamosi A, Yandutse MI: Prevalence and determinants of obesity - a cross-sectional study of an adult Northern Nigerian population. Int Arch Med 2011, 4:10. BioMed Central Full Text
• [34]Cross DS, Ivacic LC, Stefanski EL, McCarty CA: Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. BMC Genet 2010, 11:51. BioMed Central Full Text
• [35]Goumidi L, Cottel D, Dallongeville J, Amouyel P, Meirhaeghe A: Effects of established BMI-associated loci on obesity-related traits in a French representative population sample. BMC Genet 2014, 15:62. BioMed Central Full Text
• [36]Hoed MD, Ekelund U, Brage S, Grontved A, Zhao JH, Sharp SJ, Ong KK, Wareham NJ, Loos RJF: Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence. Diabetes 2010, 59:2980-2988.
• [37]Cuypers KF, Loos RJF, Kvaløy K, Kulle B, Romundstad P, Holmen TL: Obesity-Susceptibility Loci and Their Influence on Adiposity-Related Traits in Transition from Adolescence to Adulthood - The HUNT Study. PLoS One 2012, 7:e46912.
• [38]van Vliet-Ostaptchouk JV, den Hoed M, Luan J, Zhao JH, Ong KK, Van Der Most PJ, Wong A, Hardy R, Kuh D, van der Klauw MM, Bruinenberg M, Khaw KT, Wolffenbuttel BHR, Wareham NJ, Snieder H, Loos RJF: Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia 2013, 56:2134-2146.
• [39]Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013, 45(5):501-512.