The association between maternal blood pressures and offspring size at birth in Southeast Asian women

BMC Pregnancy and Childbirth

An Pan³  Seang-Mei Saw³  Keith M Godfrey⁵  Peter D Gluckman⁷  Yap-Seng Chong²  Kenneth Kwek³  Chuen-Seng Tan⁴  Yung-Seng Lee⁶  Wai-Yee Lim¹ 

[1] KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore;Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 12, Singapore 119228, Singapore;Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive (MD6), Singapore 117597, Singapore;Saw Swee Hock School of Public Health, National University of Singapore, Block MD1, #11-01E, 12 Science Drive 2, Singapore 117549, Republic of Singapore;NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK;Singapore Institute for Clinical Sciences, A*STAR, Brenner Centre for Molecular Medicine, 30 Medical Drive, Singapore 117609, Singapore;Liggins Institute, The University of Auckland, Private Bag 92019, Victoria Street West, Auckland 1142, New Zealand

关键词: Birth weight;    Obesity;    Blood pressures;    Pregnancy;   

Others  :  1091313
DOI  :  10.1186/s12884-014-0403-1

 received in 2014-06-11, accepted in 2014-11-20,  发布年份 2014

【 摘 要 】

Background

Maternal blood pressures in pregnancy is an important determinant of offspring size at birth. However, the relationship between maternal blood pressures and offspring’s size at birth is not consistent and may vary between ethnic groups. We examined the relationship between maternal peripheral and central blood pressures and offspring size at birth in an Asian multi-ethnic cohort, and effect modifications by maternal ethnicity and obesity.

Methods

We used data from 713 participants in the Growing Up in Singapore Towards Healthy Outcomes study consisting of pregnant Chinese, Malay and Indian women recruited from two tertiary hospitals between 2009 to 2010. Peripheral systolic and diastolic blood pressures (SBP and DBP), and central SBP and pulse pressure (PP) were measured around 27 weeks of gestation. Biometric parameters at birth were collected from medical records.

Results

After adjusting for maternal and fetal covariates, each 1-SD increase (10.0 mmHg) in central SBP was inversely associated with birth weight (−40.52 g; 95% confidence interval (CI) -70.66 to −10.37), birth length (−0.19 cm; −0.36 to −0.03), head circumference (−0.12 cm; −0.23 to −0.02) and placental weight (−11.16 g; −20.85 to −1.47). A one-SD (11.1 mmHg) increase in peripheral SBP was also associated with lower birth weight (−35.56 g; −66.57 to −4.54). The inverse relations between other blood pressure measures and offspring size at birth were observed but not statistically significant. Higher peripheral SBP and DBP and central SBP were associated with increased odds of low birth weight (defined as weight <2500 g) and small for gestational age (defined as <10^th percentile for gestational age adjusted birth weight). Maternal adiposity modified these associations, with stronger inverse associations in normal weight women. No significant interactions were found with ethnicity.

Conclusions

Higher second-trimester peripheral and central systolic pressures were associated with smaller offspring size at birth, particularly in normal weight women. Findings from this study reinforces the clinical relevance of antenatal blood pressure monitoring.

【 授权许可】

   
2014 Lim et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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