Assessment of central haemomodynamics from a brachial cuff in a community setting

BMC Cardiovascular Disorders

Carl Heneghan¹  Alison Ward¹  Susannah Fleming¹  Bernhard Hametner²  Daniel Lasserson¹  Siegfried Wassertheurer²  David Nunan¹ 

[1] Department of Primary Care Health Sciences, University of Oxford, Hythe Bridge St, Oxford, UK;AIT Austrian Institute of Technology GmbH, Donau-City-Straße 1, 1220, Vienna, Austria

关键词: Validation;    Primary care;    Hypertension;    Augmentation;    Central pressure;   

Others  :  1084815
DOI  :  10.1186/1471-2261-12-48

 received in 2011-12-14, accepted in 2012-06-15,  发布年份 2012

【 摘 要 】

Background

Large artery stiffening and wave reflections are independent predictors of adverse events. To date, their assessment has been limited to specialised techniques and settings. A new, more practical method allowing assessment of central blood pressure from waveforms recorded using a conventional automated oscillometric monitor has recently been validated in laboratory settings. However, the feasibility of this method in a community based setting has not been assessed.

Methods

One-off peripheral and central haemodynamic (systolic and diastolic blood pressure (BP) and pulse pressure) and wave reflection parameters (augmentation pressure (AP) and index, AIx) were obtained from 1,903 volunteers in an Austrian community setting using a transfer-function like method (ARCSolver algorithm) and from waveforms recorded with a regular oscillometric cuff. We assessed these parameters for known differences and associations according to gender and age deciles from <30 years to

>

80 years in the whole population and a subset with a systolic BP < 140 mmHg.

Results

We obtained 1,793 measures of peripheral and central BP, PP and augmentation parameters. Age and gender associations with central haemodynamic and augmentation parameters reflected those previously established from reference standard non-invasive techniques under specialised settings. Findings were the same for patients with a systolic BP below 140 mmHg (i.e. normotensive). Lower values for AIx in the current study are possibly due to differences in sampling rates, detection frequency and/or averaging procedures and to lower numbers of volunteers in younger age groups.

Conclusion

A novel transfer-function like algorithm, using brachial cuff-based waveform recordings, provides robust and feasible estimates of central systolic pressure and augmentation in community-based settings.

【 授权许可】

   
2012 Nunan et al.; licensee BioMed Central Ltd.

【 图 表 】

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