Human immunodeficiency virus-associated Burkitt lymphoma in a Japanese patient with early submandibular swelling: a case report

BMC Research Notes

Tsuyoshi Takato³  Mineo Kurokawa²  Yasuhiko Kamikubo¹  Yoshiyuki Mori³  Yoko Kawase-Koga³  Noriko Komatsu³ 

[1] Human Health Science, Faculty of Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Syogoin, Sakyu-ku, Kyoto 606-8507, Japan;Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan;Department of Oral and Maxillofacial Surgery, Dentistry and Orthodontics, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

关键词: Submandibular swelling;    HIV;    Burkitt lymphoma;   

Others  :  1135082
DOI  :  10.1186/1756-0500-6-557

 received in 2013-05-18, accepted in 2013-12-16,  发布年份 2013

【 摘 要 】

Background

Patients infected with the human immunodeficiency virus (HIV) are at risk of developing malignancies and have an increased susceptibility to infection. HIV-associated Burkitt lymphoma (BL) is relatively rare in developed countries, but remains prevalent in developing counties and is sometimes compounded by the fact that patients may be unaware that they are HIV-positive.

Case presentation

A 37-year-old Japanese man was referred to our department for diagnosis and management of submandibular swelling. He was unaware that he was HIV-positive at the initial visit. Here, we describe our diagnostic approach, in which we used hematological and immunological investigations, biopsy, fluorescence-activated cell sorting and fluorescence in situ hybridization to confirm the diagnosis of HIV-associated BL. The patient has no risk factors for HIV infection, and the source of infection remains unclear.

Conclusions

In this case, submandibular swelling was the first clinical sign of pathology and the patient’s HIV-positive status only became evident later. It is highly likely that BL was triggered by HIV infection.

【 授权许可】

   
2013 Komatsu et al.; licensee BioMed Central Ltd.

【 图 表 】

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