Burkitt lymphoma presenting with nasopharyngeal mass and generalized lymphadenopathy in a HIV-positive patient

The Egyptian Journal of Haematology

article

Manasi Mundada¹  Faiq Ahmed¹  Rachna Khera¹  Sudha Murthy¹  Pavan Kumar Boyella¹ 

[1] Department of Laboratory Medicine, Basvatarakam Indo American Cancer Hospital and Research Institute

关键词: Burkitt lymphoma;    HIV;    nasopharyngeal mass;   

DOI  :  10.4103/ejh.ejh_29_19

来源: Medknow

【 摘 要 】

Burkitt lymphoma is an aggressive B-cell neoplasm arising from the germinal center B cells. Clinically, it exists in three forms: endemic, sporadic, and immunodeficiency associated. Immunodeficiency-associated Burkitt lymphoma is usually extranodal and occurs with a CD4 count more than 200 μl. We report a retrospective study of a 47-year-old male patient, seropositive for HIV infection, presenting with nasopharyngeal mass and generalized lymphadenopathy. His CD4 count was 192 cells/μl, and lactate dehydrogenase was high. Diagnosis was established by biopsy, immunohistochemistry, and fluorescence in-situ hybridization. He was treated with chemotherapy. The disease progressed to involve central nervous system despite treatment. He received palliative radiotherapy and was stable at 11-month follow-up. This report highlights the uncommon clinical presentation, heavy disease burden, and progression of the disease in a HIV seropositive patient.

【 授权许可】

Unknown