Lipocalin 2 in cerebrospinal fluid as a marker of acute bacterial meningitis

BMC Infectious Diseases

Muhamed-Kheir Taha¹  Dario Giorgini¹  Ala-Eddine Deghmane¹  Tamazoust Guiddir¹ 

[1] Institut Pasteur, Invasive Bacterial Infections Unit and National Reference Centre for Meningococci, 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France

关键词: Diagnosis;    Cerebrospinal fluid;    Inflammation;    Lipocalin 2;    Meningitis;   

Others  :  1127761
DOI  :  10.1186/1471-2334-14-276

 received in 2013-10-25, accepted in 2014-05-06,  发布年份 2014

【 摘 要 】

Background

Early differential diagnosis between acute bacterial and viral meningitis is problematic. We aimed to investigate whether the detection of lipocalin 2, a protein of the acute innate immunity response, may be used as a marker for acute bacterial meningitis.

Methods

Transgenic mice expressing the human transferrin were infected by intraperitoneal route and were imaged. Cerebrospinal fluid (CSF) was sampled up to 48hours post- infection to measure lipocalin 2. We also tested a collection of 90 and 44 human CSF with confirmed acute bacterial or acute viral meningitis respectively.

Results

Lipocalin 2 was detected after 5 h in CSF during experimental infection in mice. Lipocalin 2 levels were significantly higher (p < 0.0001) in patients with confirmed acute bacterial meningitis (mean 125 pg/mL, range 106–145 pg/mL) than in patients with acute viral meningitis (mean 2 pg/mL, range 0–6 pg/mL) with a sensitivity of 81%, a specificity of 93%, a positive predictive value of 96% and a negative predictive value of 71% in diagnosing acute bacterial meningitis.

Conclusions

Increased levels of lipocalin 2 in cerebrospinal fluid may discriminate between acute bacterial and viral meningitis in patients with clinical syndrome of meningitis.

【 授权许可】

   
2014 Guiddir et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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