Neuroschistosomiasis due to Schistosoma mansoni: a review of pathogenesis, clinical syndromes and diagnostic approaches

Revista do Instituto de Medicina Tropical de São Paulo

Cristiana M. Nascimento-carvalho²  Otávio A. Moreno-carvalho¹ 

[1],Federal University of Bahia Faculty of Medicine Department of PediatricsSalvador Bahia ,Brasil

关键词: Neuroschistosomiasis;    Diagnosis;    Cerebrospinal fluid;    Magnetic resonance imaging;    Schistosoma mansoni;   

DOI  :  10.1590/S0036-46652005000400001

来源: SciELO

【 摘 要 】

Neuroschistosomiasis (NS) is the second most common form of presentation of infection by the trematode, Schistosoma mansoni. Granulomatous inflammatory reaction occurs as a result of schistosome eggs being transmitted to spinal cord or brain via the vascular system, or by inadvertent adult worm migration to these organs. The two main clinical syndromes are spinal cord neuroschistosomiasis (acute or subacute myelopathy) and localized cerebral or cerebellar neuroschistosomiasis (focal CNS impairment, seizures, increased intracranial pressure). Presumptive diagnosis of NS requires confirming the presence of S. mansoni infection by stool microscopy or rectal biopsy for trematode eggs, and serologic testing of blood and spinal fluid. The localized lesions are identified by signs and symptoms, and confirmed by imaging techniques (contrast myelography, CT and MRI). Algorithms are presented to allow a stepwise approach to diagnosis.

【 授权许可】

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