Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation

BMC Nephrology

Charles L Edelstein¹  Connie L Davis²  Prasad Devarajan³  Kim McFann¹  Alkesh Jani¹  Sarah Faubel¹  Angela Walcher¹  Jeffrey C Sirota¹ 

[1] Division of Renal Diseases and Hypertension, University of Colorado at Denver Health Sciences Center, Box C281, 12700 East 19th Ave, Aurora, CO 80262, USA;Division of Nephrology, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA;Division Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML 7022, Cincinnati, OH, USA

关键词: Liver transplantation;    Acute kidney injury;    Biomarkers;   

Others  :  1083021
DOI  :  10.1186/1471-2369-14-17

 received in 2012-06-29, accepted in 2013-01-11,  发布年份 2013

【 摘 要 】

Background

AKI is common following liver transplantation and is associated with significant morbidity and mortality. Biomarkers of AKI have not been well established in this setting but are needed to help guide patient care and facilitate development of novel therapeutics.

Methods

Serum creatinine, cystatin C, IL-6, and IL-8 and urine IL-18, NGAL, IL-6, and IL-8 were measured before and within 24 hours after liver transplantation in 40 patients. AKI was defined as a ≥50% sustained increase in creatinine above pre-operative values occurring within 24 hours of transplantation and persisting for at least 24 hours.

Results

Seven patients met criteria for AKI (17.5%), with mean creatinines of 0.81 mg/dL pre-operatively and 1.75 mg/dL post-operatively. While pre-operative biomarker levels in patients with AKI were similar to those in patients without AKI, differences were seen between the groups with regard to median post-operative serum IL-8 (pg/mL) (242.48 vs. 82.37, p = 0.0463) and urine NGAL (ng/mL) (386.86 vs. 24.31, p = 0.0039), IL-6 (pg/mL) (52 vs. 7.29, p=0.0532), IL-8 (pg/mL) (14.3 vs. 0, p = 0.0224), and IL-18 (pg/mL) (883.09 vs. 0, p = 0.0449). The areas under receiver operating characteristic (ROC) curves were 0.749 for urine IL-18, 0.833 for urine NGAL, 0.745 for urine IL-6, 0.682 for serum IL-6, 0.773 for urine IL-8, and 0.742 for serum IL-8. Post-operative cystatin C was not significantly different between AKI and no AKI groups.

Conclusion

Serum IL-8 and urine IL-18, NGAL, IL-6, and IL-8 are elevated in AKI within the first 24 hours following liver transplantation.

【 授权许可】

   
2013 Sirota et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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