Central retinal vein occlusion in a pediatric patient with SLE and antiphospholipid antibodies without anti-cardiolipin or anti-β2 glycoprotein I antibodies

BMC Pediatrics

Tatsuro Izumi¹  Toshiaki Kubota²  Ryoko Ohki²  Chika Gotoh¹  Hironori Goto¹  Seigo Korematsu¹ 

[1] Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Hasama, Yufu, Oita 879-5593, Japan;Department of Ophthalmology, Oita University Faculty of Medicine, Hasama, Yufu, Oita 879-5593, Japan

关键词: Anti-phosphatidylcholine antibody;    Antiphospholipid antibody syndrome;    Systemic lupus erythematosus;    Central retinal vein occlusion;   

Others  :  1138878
DOI  :  10.1186/1471-2431-14-116

 received in 2013-11-22, accepted in 2014-05-01,  发布年份 2014

【 摘 要 】

Background

Antiphospholipid antibody syndrome is characterized by venous and/or arterial thrombosis, and is found in patients with systemic lupus erythematosus. Its diagnosis requires the presence of both clinical and laboratory findings, such as positive anti-cardiolipin and anti-β2 glycoprotein I antibodies and lupus anticoagulant. However, cardiolipin is a minor component of the vascular endothelial cells in human, and phosphatidylcholine and phosphatidylethanolamine are major components.

Case presentation

A 15-year-old female suddenly developed massive left intraretinal hemorrhaging due to central retinal vein occlusion. She also had a butterfly rash, and her laboratory findings revealed positive serum anti-nuclear antibodies and decreased serum complement. During this episode, she was diagnosed with systemic lupus erythematosus. Although she was negative for serum anti-cardiolipin IgG and anti-β2 glycoprotein I antibodies as well as lupus anticoagulant, her serum anti-phosphatidylcholine, anti-phosphatidylethanolamine, anti-phosphatidylinositol and phosphatidylserine IgG antibodies levels were increased.

Conclusion

Pediatric cases of central retinal vein occlusion are rare. Even in patients without anti-cardiolipin or anti-β2 glycoprotein I antibodies and lupus anticoagulant, there is the potential for the development of antiphospholipid antibody-related thrombosis.

【 授权许可】

   
2014 Korematsu et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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