Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification

BMC Complementary and Alternative Medicine

Simon M N Efange⁶  Wolfgang Sippl²  Philip N Judson³  Eugene Megnassan⁷  Luc C Owono Owono⁴  Nnange Ekwelle⁵  Luc Meva’a Mbaze⁸  Lydia Likowo Lifongo⁶  Fidele Ntie-Kang¹ 

[1] CEPAMOQ, Faculty of Science, University of Douala, P.O. Box 8580 Douala, Cameroon;Department of Pharmaceutical Sciences, Martin-Luther University of Halle-Wittemberg, Wolfgang-Langenbeck Str. 4,06120 Halle(Saale), Germany;Chemical and Bioactivity Information Centre, 22-23 Blenheim Terrace, Woodhouse Lane, Leeds LS2 9HD UK;Laboratory for Simulations and Biomolecular Physics, Ecole Normale Supérieure, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon;Klinikum Südstadt, Südring 81, 18055 Rostock, Germany;Chemical and Bioactivity Information Centre, Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63 Buea, Cameroon;Laboratory of Fundamental and Applied Physics, University of Abobo-Adjame, Abidjan 02 BP 801 Cote d’Ivoire;Department of Chemistry, Faculty of Science, University of Douala, P. O. Box 24157, Douala, Cameroon

关键词: Natural products;    Medicinal plants;    Ethnobotany;    Chemotaxonomy;    Biological activities;   

Others  :  1229433
DOI  :  10.1186/1472-6882-13-147

 received in 2013-03-07, accepted in 2013-06-18,  发布年份 2013

【 摘 要 】

Background

In Cameroon herbs are traditionally used to meet health care needs and plans are on the way to integrate traditional medicine in the health care system, even though the plans have not been put into action yet. The country however has a rich biodiversity, with ~8,620 plant species, some of which are commonly used in the treatment of several microbial infections and a range of diseases (malaria, trypanosomiasis, leishmaniasis, diabetes and tuberculosis).

Methods

Our survey consisted in collecting published data from the literature sources, mainly from PhD theses in Cameroonian university libraries and also using the author queries in major natural product and medicinal chemistry journals. The collected data includes plant sources, uses of plant material in traditional medicine, plant families, region of collection of plant material, isolated metabolites and type (e.g. flavonoid, terpenoid, etc.), measured biological activities of isolated compounds, and any comments on significance of isolated metabolites on the chemotaxonomic classification of the plant species. This data was compiled on a excel sheet and analysed.

Results

In this study, a literature survey led to the collection of data on 2,700 secondary metabolites, which have been previously isolated or derived from Cameroonian medicinal plants. This represents distinct phytochemicals derived from 312 plant species belonging to 67 plant families. The plant species are investigated in terms of chemical composition with respect to the various plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants is also attempted. Insight into future direction for natural product search within the Cameroonian forest and Savanna is provided.

Conclusions

It can be verified that a phytochemical search of active secondary metabolites, which is inspired by knowledge from the ethnobotanical uses of medicinal plants could be very vital in a drug discovery program from plant-derived bioactive compounds.

【 授权许可】

   
2013 Ntie-Kang et al.; licensee BioMed Central Ltd.

【 图 表 】

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