Parathyroid adenoma detected with 99mTc-tetrofosmin dual-phase scintigraphy: a case report

BMC Research Notes

Michael Pitiakoudis³  Constantinos Simopoulos³  Theodosia Vogiatzaki¹  Athanassios Zissimopoulos⁴  Efthimios Sibridis²  Alexandra Giatromanolaki²  Eleni-Aikaterini Nagorni³  Evangelos Karathanos⁴  Konstantinos Romanidis³ 

[1]Department of Anaesthesiology, Democritus University of Thrace, Alexandroupolis, Greece

[2]Department of Pathology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece

[3]Second Department of Surgery, Medical School, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece

[4]Department of Nuclear Medicine, Medical School, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece

关键词: Parathyroidectomy;    Parathormone;    Nuclear medicine;    p-glycoprotein;    ^99mTc-tetrofosmin dual-phase scintigraphy;    Parathyroid adenoma;   

Others  :  1132588
DOI  :  10.1186/1756-0500-7-335

 received in 2013-10-13, accepted in 2014-05-26,  发布年份 2014

【 摘 要 】

Background

Tc-sestamibi is the most frequently used radionuclide agent for the detection of parathyroid adenomas in the clinical setting. However, Tc-tetrofosmin is another such agent that may be used for this purpose. This case report presents the significance and practicality of ^99mTc-tetrofosmin for the diagnosis of parathyroid adenomas with probable high p-glycoprotein levels.

Case presentation

A 45-year-old woman was referred to our Nuclear Department with a palpable neck nodule suspicious for parathyroid adenoma. She had no significant medical history or other accompanying symptoms. Blood examination results were normal with the exception of the parathormone level which was high at 167.2 pg/ml. Neck ultrasonography revealed a hypoechoic mass near the lower pole of the thyroid gland. ^99m Tc-tetrofosmin dual-phase scintigraphy with early and delayed images was performed and the results supported the presupposition of parathyroid adenoma as shown by increased radiopharmaceutical levels near the lower left thyroid gland on the early image that disappeared on the delayed image. Moreover, TcO₄⁻ thyroid scintigraphy results excluded thyroid pathology. Two months after the diagnosis, parathyroidectomy was successfully performed without postoperative complications. The pathology report and clinical response to a gradual decrease of parathormone confirmed the initial diagnosis.

Conclusion

We strongly recommend the use of reverse ^99m Tc-tetrofosmin scintigraphy as a useful and safe examination technique for the diagnosis of parathyroid adenomas.

【 授权许可】

   
2014 Romanidis et al.; licensee BioMed Central Ltd.

【 图 表 】

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