Subgenotype reclassification of genotype B hepatitis B virus

BMC Gastroenterology

Zhong Zhang¹  Desmond G Higgins⁶  Michael J Carr⁵  Wei Zheng²  Chaodong Zhu⁴  Weifeng Shi³ 

[1] Department of Basic Medicine, Taishan Medical College, Taian, 271000, Shandong, China;Graduate University of Chinese Academy of Sciences, Beijing, 100049, China;Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Nansha, 511458, Guangzhou, China;Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China;National Virus Reference Laboratory, University College Dublin, Dublin, 4, Ireland;The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, 4, Ireland

关键词: Sequence divergence;    Phylogenetic analysis;    Subgenotype;    Hepatitis B virus;   

Others  :  1088684
DOI  :  10.1186/1471-230X-12-116

 received in 2012-06-26, accepted in 2012-08-24,  发布年份 2012

【 摘 要 】

Background

Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addition, subgenotype B6 was designated twice for viruses of different origin.

Methods

All complete genome sequences of genotype B HBV were phylogenetically analyzed. Sequence divergences between different potential subgenotypes were also assessed.

Results

Both phylogenetic and sequence divergence analyses supported the designation of subgenotypes B1, B2, B4, and B6 (from Arctic). However, sequence divergences between previously designated B3, B5, B7, B8, B9 and another B6 (from China) were mostly less than 4%. In addition, subgenotype B3 did not form a monophyly.

Conclusion

Current evidence failed to classify original B5, B7, B8, B9, and B6 (from China) as subgenotypes. Instead, they could be considered as a quasi-subgenotype B3 of Southeast Asian and Chinese origin. In addition, previously designated B6 (from Arctic) should be renamed as B5 for continuous numbering. This novel classification is well supported by both the phylogeny and sequence divergence of > 4%.

【 授权许可】

   
2012 Shi et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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