Reproducibility of a peripheral quantitative computed tomography scan protocol to measure the material properties of the second metatarsal

BMC Musculoskeletal Disorders

Gordon J Hendry⁷  Daniel J Schiferl⁴  Keith Rome³  Joshua Burns⁶  Davinder Singh-Grewal⁶  Verona du Toit²  Scott Telfer⁷  Anita Hood⁵  David Greene⁸  Elodie Chaplais¹ 

[1] Clermont Université, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques, Clermont-Ferrand, France;School of Medicine, University of Western Sydney, Penrith, NSW, Australia;Department of Podiatry, Health and Rehabilitation Research Institute, School of Rehabilitation & Occupational Studies, AUT, Auckland, New Zealand;Bone Diagnostic Inc, Fort Atkinson, WI, USA;Podiatry Department, Concord Hospital, South Western Sydney Local Health District, Sydney, NSW, Australia;The University of Sydney and Sydney Children’s Hospitals Network (Randwick and Westmead), Sydney, NSW, Australia;Institute for Applied Health Research, Glasgow Caledonian University, Glasgow G4 0BA, UK;School of Exercise Science, Australian Catholic University, Strathfield, NSW, Australia

关键词: Insufficiency fracture;    Osteoporosis;    Foot;    2^nd metatarsal;    Fracture risk;    pQCT;   

Others  :  1122338
DOI  :  10.1186/1471-2474-15-242

 received in 2014-01-22, accepted in 2014-07-16,  发布年份 2014

【 摘 要 】

Background

Peripheral quantitative computed tomography (pQCT) is an established technology that allows for the measurement of the material properties of bone. Alterations to bone architecture are associated with an increased risk of fracture. Further pQCT research is necessary to identify regions of interest that are prone to fracture risk in people with chronic diseases. The second metatarsal is a common site for the development of insufficiency fractures, and as such the aim of this study was to assess the reproducibility of a novel scanning protocol of the second metatarsal using pQCT.

Methods

Eleven embalmed cadaveric leg specimens were scanned six times; three times with and without repositioning. Each foot was positioned on a custom-designed acrylic foot plate to permit unimpeded scans of the region of interest. Sixty-six scans were obtained at 15% (distal) and 50% (mid shaft) of the second metatarsal. Voxel size and scan speed were reduced to 0.40 mm and 25 mm.sec^-1. The reference line was positioned at the most distal portion of the 2^nd metatarsal. Repeated measurements of six key variables related to bone properties were subject to reproducibility testing. Data were log transformed and reproducibility of scans were assessed using intraclass correlation coefficients (ICC) and coefficients of variation (CV%).

Results

Reproducibility of the measurements without repositioning were estimated as: trabecular area (ICC 0.95; CV% 2.4), trabecular density (ICC 0.98; CV% 3.0), Strength Strain Index (SSI) - distal (ICC 0.99; CV% 5.6), cortical area (ICC 1.0; CV% 1.5), cortical density (ICC 0.99; CV% 0.1), SSI – mid shaft (ICC 1.0; CV% 2.4). Reproducibility of the measurements after repositioning were estimated as: trabecular area (ICC 0.96; CV% 2.4), trabecular density (ICC 0.98; CV% 2.8), SSI - distal (ICC 1.0; CV% 3.5), cortical area (ICC 0.99; CV%2.4), cortical density (ICC 0.98; CV% 0.8), SSI – mid shaft (ICC 0.99; CV% 3.2).

Conclusions

The scanning protocol generated excellent reproducibility for key bone properties measured at the distal and mid-shaft regions of the 2^nd metatarsal. This protocol extends the capabilities of pQCT to evaluate bone quality in people who may be at an increased risk of metatarsal insufficiency fractures.

【 授权许可】

   
2014 Chaplais et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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