Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children

BMC Medical Genetics

Vanessa Suñé Mattevi²  Silvana Almeida³  Liane Nanci Rotta³  Paula Dal Bó Campagnolo³  Márcia Regina Vitolo³  Marília Remuzzi Zandoná³  Carmela Farias da Silva¹ 

[1] Programa de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil;Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245, sala 309, Porto Alegre, RS, CEP 90050-170, Brazil;Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil

关键词: FTO gene and genetic susceptibility;    Childhood obesity;   

Others  :  1177719
DOI  :  10.1186/1471-2350-14-34

 received in 2012-06-08, accepted in 2013-03-07,  发布年份 2013

【 摘 要 】

Background

Our goal was to analyze the association of the fat mass and obesity- associated (FTO) gene rs9939609 variant (T/A) with the anthropometric and dietary intake phenotypes related to obesity in Brazilian children.

Methods

We analyzed the association of this single nucleotide polymorphism (SNP) with phenotypes related to the accumulation of body mass in a cohort of 348 children followed from the time of birth until 8 years old and then replicated the main findings in an independent schoolchildren sample (n = 615).

Results

At the age of 4, we observed a significant association between the A/A genotype and a higher mean BMI Z-score (P = 0.036). At the age of 8, the A/A individuals still presented with a higher BMI Z-score (P = 0.011) and with marginal differences in the volume of subcutaneous fat (P = 0.048). We replicated these findings in the schoolchildren sample, which showed that those with at least one copy of the A allele presented with a higher BMI Z-score (P = 0.029) and volume of subcutaneous fat (P = 0.016).

Conclusion

Our results indicate that this FTO variant is associated with increased body mass and subcutaneous fat in Brazilian children beginning at the age of 4.

【 授权许可】

   
2013 da Silva et al.; licensee BioMed Central Ltd.

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