The Vermont oxford neonatal encephalopathy registry: rationale, methods, and initial results

BMC Pediatrics

Roger F Soll²  Tonse Raju²  Karin B Nelson²  Terrie Inder²  Michael J Kenny¹  Jeffrey D Horbar²  Erika M Edwards¹  Peter Bingham²  Robert H Pfister¹ 

[1] Vermont Oxford Network, Burlington, VT, USA;Vermont Oxford Network Neonatal Encephalopathy Registry Steering Committee Member, Burlington, USA

关键词: Registry;    Neonatal encephalopathy;    Neuroprotection;    Cooling;    Asphyxia;    Therapeutic hypothermia;    HIE;    Neonatal encephalopathy;    Hypoxic ischemic encephalopathy;   

Others  :  1170759
DOI  :  10.1186/1471-2431-12-84

 received in 2012-02-09, accepted in 2012-06-04,  发布年份 2012

【 摘 要 】

Background

In 2006, the Vermont Oxford Network (VON) established the Neonatal Encephalopathy Registry (NER) to characterize infants born with neonatal encephalopathy, describe evaluations and medical treatments, monitor hypothermic therapy (HT) dissemination, define clinical research questions, and identify opportunities for improved care.

Methods

Eligible infants were ≥ 36 weeks with seizures, altered consciousness (stupor, coma) during the first 72 hours of life, a 5 minute Apgar score of ≤ 3, or receiving HT. Infants with central nervous system birth defects were excluded.

Results

From 2006–2010, 95 centers registered 4232 infants. Of those, 59% suffered a seizure, 50% had a 5 minute Apgar score of ≤ 3, 38% received HT, and 18% had stupor/coma documented on neurologic exam. Some infants experienced more than one eligibility criterion. Only 53% had a cord gas obtained and only 63% had a blood gas obtained within 24 hours of birth, important components for determining HT eligibility. Sixty-four percent received ventilator support, 65% received anticonvulsants, 66% had a head MRI, 23% had a cranial CT, 67% had a full channel encephalogram (EEG) and 33% amplitude integrated EEG. Of all infants, 87% survived.

Conclusions

The VON NER describes the heterogeneous population of infants with NE, the subset that received HT, their patterns of care, and outcomes. The optimal routine care of infants with neonatal encephalopathy is unknown. The registry method is well suited to identify opportunities for improvement in the care of infants affected by NE and study interventions such as HT as they are implemented in clinical practice.

【 授权许可】

   
2012 Pfister et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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