期刊论文详细信息
BMC Musculoskeletal Disorders
The effect of physical loading on calcaneus quantitative ultrasound measurement: a cross-section study
De-Yu Li1  Yu-Bo Fan1  Lian-Wen Sun1  Ling Wang1  Fang Pu1  Hai-Jun Niu1  Cheng-Rui Liu1 
[1] Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, XueYuan Road No.37, Beijing, 100191, People’s Republic of China
关键词: Menopause;    Physical loading;    Osteoporosis;    Quantitative ultrasound;   
Others  :  1149865
DOI  :  10.1186/1471-2474-13-70
 received in 2011-05-22, accepted in 2012-04-17,  发布年份 2012
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【 摘 要 】

Background

Physical loading leads to a deformation of bone microstructure and may influence quantitative ultrasound (QUS) parameters. This study aims at evaluating the effect of physical loading on bone QUS measurement, and further, on the potential of diagnosing osteoporosis using QUS method under physical loading condition.

Methods

16 healthy young females (control group) and 45 postmenopausal women (divided into 3 groups according to the years since menopause (YSM)) were studied. QUS parameters were measured at calcaneus under self-weight loading (standing) and no loading (sitting) conditions. Weight-normalized QUS parameter (QUS parameter measured under loading condition divided by the weight of the subject) was proposed to evaluate the influence of loading. T-test, One-Way analysis of variance (one way ANOVA) and receiver operating characteristic (ROC) analysis were applied for analysis.

Results

In QUS parameters, mainly normalized broadband ultrasound attenuation (nBUA), measured with loading significantly differed from those measured without loading (p < 0.05). The relative changes of weight-normalized QUS parameters on postmenopausal women with respect to premenopausal women under loading condition were larger than those on traditional QUS parameters measured without loading. In ROC analysis, weight-normalized QUS parameters showed their stronger discriminatory ability for menopause.

Conclusions

Physical loading substantially influenced bone QUS measurement (mainly nBUA). Weight-normalized QUS parameters can discriminate menopause more effectively. By considering the high relationship between menopause and osteoporosis, an inference was drawn that adding physical loading during measurement may be a probable way to improve the QUS based osteoporosis diagnosis.

【 授权许可】

   
2012 Liu et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Blanchard F: Report on osteoporosis in the european community: building strong bones and preventing fractures-action for prevention. European Communities, In. Brussels; 1998.
  • [2]Kanis JA, Gluer CC: An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation. Osteoporos Int 2000, 11(3):192-202.
  • [3]Johnell O, Kanis JA, Oden A, Johansson H, De Laet C, Delmas P, Eisman JA, Fujiwara S, Kroger H, Mellstrom D, et al.: Predictive value of BMD for hip and other fractures. J Bone Miner Res 2005, 20(7):1185-1194.
  • [4]Tauchmanova L, Nuzzo V, Del PA, Fonderico F, Esposito-Del PA, Padulla S, Rossi A, Bifulco G, Lupoli G, Lombardi G: Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre and postmenopausal women with endogenous subclinical hyperthyroidism. Maturitas 2004, 48(3):299-306.
  • [5]Goldstein SA, Goulet R, McCubbrey D: Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone. Calcif Tissue Int 1993, 53(Suppl 1):S127-S132. S132-S133
  • [6]Resch H, Pietschmann P, Bernecker P, Krexner E, Willvonseder R: Broadband ultrasound attenuation: a new diagnostic method in osteoporosis. AJR Am J Roentgenol 1990, 155(4):825-828.
  • [7]Gluer CC: Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status. The international quantitative ultrasound consensus group. J Bone Miner Res 1997, 12(8):1280-1288.
  • [8]Hans D, Wu C, Njeh CF, Zhao S, Augat P, Newitt D, Link T, Lu Y, Majumdar S, Genant HK: Ultrasound velocity of trabecular cubes reflects mainly bone density and elasticity. Calcif Tissue Int 1999, 64(1):18-23.
  • [9]Nicholson PH, Muller R, Cheng XG, Ruegsegger P, Van Der Perre G, Dequeker J, Boonen S: Quantitative ultrasound and trabecular architecture in the human calcaneus. J Bone Miner Res 2001, 16(10):1886-1892.
  • [10]Muller M, Mitton D, Moilanen P, Bousson V, Talmant M, Laugier P: Prediction of bone mechanical properties using QUS and pQCT: Study of the human distal radius. Med Eng Phys 2008, 30(6):761-767.
  • [11]Barkmann R, Laugier P, Moser U, Dencks S, Padilla F, Haiat G, Heller M, Gluer CC: A method for the estimation of femoral bone mineral density from variables of ultrasound transmission through the human femur. Bone 2007, 40(1):37-44.
  • [12]Trimpou P, Bosaeus I, Bengtsson B, Landin-Wilhelmsen K: High correlation between quantitative ultrasound and DXA during 7 years of follow-up. Eur J Radiol 2010, 73:360-364.
  • [13]Qin YX, Lam H, Zhang M, Orzechowski L: Dynamic skeletal muscle contraction induced bone fluid pressure and its role in adaptation. J Biomech 2007, 40(S2):S37.
  • [14]Muller R, Gerber SC, Hayes WC: Micro-compression: a novel technique for the nondestructive assessment of local bone failure. Technol Health Care 1998, 6(5–6):433-444.
  • [15]Biot MA: Theory of propagation of elastic waves in a fluid-saturated porous solid. II. Higher frequency range. J Acoust Soc Am 1956, 28(2):179-191.
  • [16]Barkmann R, Heller M, Glüer CC: Methoden der in vivo-ultraschall-messtechnik am skelett: grundlagen und technische realisierung. J Miner Stoffwechs 1999, 6(4):22-27.
  • [17]Njeh CF, Fuerst T, Diessel E, Genant HK: Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int 2001, 12(1):1-15.
  • [18]Nicholson PH, Cheng XG, Lowet G, Boonen S, Davie MW, Dequeker J, Van der Perre G: Structural and material mechanical properties of human vertebral cancellous bone. Med Eng Phys 1997, 19(8):729-737.
  • [19]Vu T, Khan NC, Lam NT, Mai LB, DucSon N, Nhung BT, Nakamori M, Kunii D, Sakai T, Yamamoto S: Determining the prevalence of osteoporosis and related factors using quantitative ultrasound in Vietnamese adult women. Am J Epidemiol 2005, 161(9):824-830.
  • [20]Falgarone G, Porcher R, Duche A, Kolta S, Dougados M, Roux C: Discrimination of osteoporotic patients with quantitative ultrasound using imaging or non-imaging device. Joint Bone Spine 2004, 71(5):419-423.
  • [21]Langton CM, Palmer SB, Porter RW: The measurement of broadband ultrasonic attenuation in cancellous bone. ARCHIVE: Engineering in Medicine 1984, 13(2):89-91. 1971–1988 (vols 1–17)
  • [22]Serpe LJ, Rho JY: Broadband ultrasound attenuation value dependence on bone width in vitro. Phys Med Biol 1996, 41:197.
  • [23]Langton CM, Njeh CF: The measurement of broadband ultrasonic attenuation in cancellous bone-a review of the science and technology. Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on 2008, 55(7):1546-1554.
  • [24]Haiat G, Padilla F, Barkmann R, Gluer CC, Laugier P: Numerical simulation of the dependence of quantitative ultrasonic parameters on trabecular bone microarchitecture and elastic constants. Ultrasonics 2006, 44:e289-e294.
  • [25]Wright TM, Vosburgh F, Burstein AH: Permanent deformation of compact bone monitored by acoustic emission. J Biomech 1981, 14(6):405-409.
  • [26]Drozdzowska B: Quantitative ultrasound measurements at the calcaneus in natural and surgically induced menopause. Maturitas 2006, 53(1):107-113.
  • [27]Adami S, Giannini S, Giorgino R, Isaia G, Maggi S, Sinigaglia L, Filipponi P, Crepaldi G, Di Munno O: The effect of age, weight, and lifestyle factors on calcaneal quantitative ultrasound: the ESOPO study. Osteoporos Int 2003, 14(3):198-207.
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