C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media

BMC Immunology

Allen F Ryan³  Stephen I Wasserman²  Nicholas Webster⁵  Kwang Pak¹  Jeffrey Pan⁴  Meredith Frie⁴  William Yao⁴ 

[1] Research Service, Veterans Administration Medical Center, San Diego 92151, CA, USA;Departments of Medicine/Allergy & Immunology, University of California, San Diego, La Jolla 92093, CA, USA;Surgery/Neuroscience, 0626, UCSD School of Medicine, 9500 Gilman Drive, La Jolla 92093-0626, CA, USA;Departments of Surgery/Otolaryngology, University of California, San Diego, La Jolla 92093, CA, USA;Departments of Medicine Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093, CA, USA

关键词: Inflammation;    Tissue proliferation;    MAP kinase signaling;    Infection;    Nontypeable haemophilus influenzae;    Middle ear;   

Others  :  1077693
DOI  :  10.1186/s12865-014-0046-z

 received in 2014-02-12, accepted in 2014-10-02,  发布年份 2014

【 摘 要 】

Background

Innate immunity and tissue proliferation play important roles in otitis media (OM), the most common disease of childhood. CJUN terminal kinase (JNK) is potentially involved in both processes.

Results

Genes involved in both innate immune and growth factor activation of JNK are upregulated during OM, while expression of both positive and negative JNK regulatory genes is altered. When compared to wildtypes (WTs), C57BL/6 mice deficient in JNK1 exhibit enhanced mucosal thickening, with delayed recovery, enhanced neutrophil recruitment early in OM, and delayed bacterial clearance. In contrast, JNK2^−/− mice exhibit delayed mucosal hyperplasia that eventually exceeds that of WTs and is slow to recover, delayed recruitment of neutrophils, and failure of bacterial clearance.

Conclusions

The results suggest that JNK1 and JNK2 play primarily opposing roles in mucosal hyperplasia and neutrophil recruitment early in OM. However, both isoforms are required for the normal resolution of middle ear infection.

【 授权许可】

   
2014 Yao et al.; licensee BioMed Central Ltd.

【 图 表 】

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