Effects of fish oil and spirulina on oxidative stress and inflammation in hypercholesterolemic hamsters

BMC Complementary and Alternative Medicine

Jane C-J Chao²  Miriam Adoyo Muga¹ 

[1]School of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan

[2]Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan

关键词: Inflammation;    Oxidative stress;    Fish oil;    Spirulina;    Hypercholesterolemia;   

Others  :  1085139
DOI  :  10.1186/1472-6882-14-470

 received in 2014-07-14, accepted in 2014-11-27,  发布年份 2014

【 摘 要 】

Background

Altered plasma lipids, oxidative stress, and inflammation have been involved in the pathogenesis of cardiovascular disease. Fish oil has shown inconclusive effects on plasma lipids and oxidative stress. Spirulina has both cholesterol lowering and antioxidant properties. However, the effect of fish oil and spirulina on hypercholesterolemia has not been studied. We investigated the effects of fish oil, spirulina, and their combination on hypercholesterolemia.

Methods

The hamsters were divided into 7 groups: control, high cholesterol (HF), fish oil (post FO), spirulina (post SP), and a combination of fish oil and spirulina (post SF, pre-SF, and HF + SF) groups. The HF and HF + SF groups were given a high cholesterol diet for 8 weeks. The post FO, post SP, and post SF groups were given a high cholesterol diet for 4 weeks and then the treatment for 4 weeks. The pre-SF group was given the combined treatment for 4 weeks and then a high cholesterol diet for 4 weeks.

Results

The HF and HF + SF groups altered plasma lipids, increased oxidative stress, inhibited antioxidants, and increased inflammation. While the post FO group increased plasma lipids and was more atherogenic. The vice versa was observed in spirulina-treated group. Both the post SP and post SF groups inhibited oxidative stress and increased antioxidant status, and post FO and post SP diets regulated pro-inflammatory cytokines to near the control levels.

Conclusions

Both single treatment of fish oil or spirulina inhibit oxidative stress and inflammation. Treatment with a combination of fish oil and spirulina (post SF) may be beneficial for diet-induced hypercholesterolemic hamsters.

【 授权许可】

   
2014 Muga and Chao; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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