Evaluation of the cytotoxicity and phototoxicity of Caryocar brasiliense supercritical carbon dioxide extract

BMC Complementary and Alternative Medicine

Priscila G Mazzola²  Mary Ann Foglio¹  Patricia Moriel²  Lilian FB Amaral² 

[1] CPQBA - Multidisciplinary Center of Chemical, Biological and Agricultural Researches, University of Campinas (UNICAMP), Rua Alexandre Cazellato, 999, Vila Betel, Paulínia, SP, Brasil;Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas (FCM-UNICAMP), Rua Tessália Vieira de Camargo, 126 Campinas, SP, Brasil

关键词: Phototoxicity;    Cytotoxicity;    Supercritical CO₂ extraction;    Pequi;   

Others  :  1085384
DOI  :  10.1186/1472-6882-14-450

 received in 2014-06-28, accepted in 2014-10-07,  发布年份 2014

【 摘 要 】

Background

Caryocar brasiliense Camb (Pequi) is a typical Brazilian Cerrado fruit tree. Its fruit is used as a vitamin source for culinary purposes and as a source of oil for the manufacture of cosmetics. C. brasiliense supercritical CO₂ extracts exhibit antimicrobial activity against the bacteria Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and also possess antioxidant activity. This study was designed to evaluate the in vitro cytotoxicity and phototoxicity of the supercritical CO₂ extract obtained from the leaves of this species.

Methods

In vitro cytotoxicity and phototoxicity of C. brasiliense supercritical CO₂ extracts were assessed using a tetrazolium-based colorimetric assay (XTT) and Neutral Red methods.

Results

We found that the C. brasiliense (Pequi) extract obtained by supercritical CO₂ extraction did not present cytotoxic and phototoxic hazards.

Conclusions

This finding suggests that the extract may be useful for the development of cosmetic and/or pharmaceutical products.

【 授权许可】

   
2014 Amaral et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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