Caffeine differentially alters cortical hemodynamic activity during working memory: a near infrared spectroscopy study

BMC Research Notes

Tino Zaehle²  Hans-Jochen Heinze²  Hermann Hinrichs²  Urs Heilbronner¹ 

[1] Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University, Munich, Germany;Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany

关键词: WM;    BOLD;    Adenosine;    Working memory;    2-back;    n-back;    Caffeine;    NIRS;   

Others  :  1229907
DOI  :  10.1186/s13104-015-1491-3

 received in 2014-12-05, accepted in 2015-09-21,  发布年份 2015

【 摘 要 】

Background

Caffeine is a widely used stimulant with potentially beneficial effects on cognition as well as vasoconstrictive properties. In functional magnetic imaging research, caffeine has gained attention as a potential enhancer of the blood oxygenation level-dependent (BOLD) response. In order to clarify changes of oxy- and deoxyhemoglobin (HbO and HbR) induced by caffeine during a cognitive task, we investigated a working memory (WM) paradigm (visual 2-back) using near-infrared spectroscopy (NIRS).

Results

Behaviorally, caffeine had no effect on the WM performance but influenced reaction times in the 0-back condition. NIRS data demonstrate caffeine-dependent alterations of the course of the hemodynamic response. The intake of 200 mg caffeine caused a significant decrease of the HbO response between 20 and 40 s after the onset of a 2-back task in the bilateral inferior frontal cortex (IFC). In parallel, the HbR response of the left IFC was significantly increased due to caffeine intake.

Conclusions

In line with previous results, we did not detect an effect of caffeine on most aspects of behavior. Effects of caffeine on brain vasculature were detected as general reduction of HbO. Neuronal effects of caffeine are reflected in an increased concentration of HbR in the left hemisphere when performing a verbal memory task and suggest influences on metabolism.

【 授权许可】

   
2015 Heilbronner et al.

【 图 表 】

Fig.1.

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