Demyelinating disease and anti-N-methyl-D-aspartate receptor immunoglobulin G antibodies: a case report

BMC Research Notes

Ralf A Linker²  De-Hyung Lee²  Angela Vincent¹  Philipp Gölitz³  Stefan Schwab²  Bernd Kallmünzer²  Anne Waschbisch² 

[1] Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK;Department of Neurology, Friedrich-Alexander University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany;Department of Neuroradiology, Friedrich-Alexander University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany

关键词: Neuroinflammation;    Anti-neuronal antibodies;    Demyelinating disease;    Encephalitis;    NMDA receptor antibody;    Multiple Sclerosis;   

Others  :  1091061
DOI  :  10.1186/1756-0500-7-948

 received in 2014-08-11, accepted in 2014-12-11,  发布年份 2014

【 摘 要 】

Background

Anti–N-methyl-D-aspartate receptor immunoglobulin G antibodies directed against the GluN1 subunit are considered highly specific for anti-N-methyl-D-aspartate receptor encephalitis, a severe clinical syndrome characterized by seizures, psychiatric symptoms, orofacial dyskinesia and autonomic dysfunction.

Case presentation

Here we report a 33 year old Caucasian male patient with clinically definite multiple sclerosis who was found to be positive for anti-N-methyl-D-aspartate receptor antibodies. Rituximab therapy was initiated. On the 18 months follow-up visit the patient was found to be clinically stable, without typical signs of anti-N-methyl-D-aspartate receptor encephalitis.

Conclusion

Our findings add to the growing evidence for a possible association between anti-N-methyl-D-aspartate receptor encephalitis and demyelinating diseases.

【 授权许可】

   
2015 Waschbisch et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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