Socio-demographic and behavioural characteristics associated with HSV-2 sero-prevalence in high risk women in KwaZulu-Natal

BMC Research Notes

Gita Ramjee³  Handan Wand¹  Nathlee Samantha Abbai² 

[1] The Kirby Institute, University of New South Wales, Sydney 2052, NSW, Australia;HIV Prevention Research Unit, Medical Research Council, 123 Jan Hofmeyr Road, Westville, Durban 3630, South Africa;Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK

关键词: Sexual behaviour;    Socio-demographic;    Multivariate analysis;    Sero-prevalence;    HSV-2;   

Others  :  1232481
DOI  :  10.1186/s13104-015-1093-0

 received in 2014-06-11, accepted in 2015-03-24,  发布年份 2015

【 摘 要 】

Background

The World Health Organization estimates that 536 million people aged 15–49 are infected with Herpes simplex virus type 2 (HSV-2), the causative agent of genital herpes. The aim of this study was to investigate the role of behavioral and demographic factors that contribute to the high HSV-2 sero-prevalence among women participating in a HIV prevention trial. The Methods for Improving Reproductive Health in Africa (MIRA) study assessed the effectiveness the latex diaphragm and lubricant gel on HIV prevention among women in South Africa and Zimbabwe. At screening an interviewer administered questionnaire on demographics and sexual behaviour was obtained. HSV-2 serum antibodies were detected using HerpeSelect™ ELISA IgG. Statistical analysis was performed using STATA release 12.0. This study was registered with ClinicalTrials.gov,number NCT00121459 on the 28th February 2007.

Findings

Of the 3 472 women screened at the Durban research sites 2 218 (73%) had a prevalent HSV-2 infection and 1431 (41%) of the women were also co-infected with HIV. In the multivariate analyses, older women (adjusted odds ratio) [aOR]: 3.49, 95% CI: (2.71,4.49) for >35 years and aOR: 1.82, 95% CI: 1.49, 2.22 for 25–34 years compared with <25 years, p < 0.001 for both comparisons were more likely to be HSV-2 sero-positive. Low level of education (OR: 1.26 95% CI: 1.03, 1.53), having >1 life-time sexual partners (OR: 2.48, 95% CI: 1.92, 3.20), parity >1 (OR: 1.95 95% CI: 1.92, 3.20) and being HIV positive (OR: 6.31, 95% CI: 5.06, 7.88) were significantly associated with HSV-2 infection.

Conclusion

The high sero-prevalence of HSV-2 in the studied population is of great public health importance since this high risk population could act as a reservoir for future infections particularly HIV transmission.

【 授权许可】

   
2015 Abbai et al.; licensee BioMed Central.

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