Indices of body fat distribution for assessment of lipodysthrophy in people living with HIV/AIDS

BMC Research Notes

Henrique Luiz Monteiro²  Alexandre Martins Portelinha Filho⁶  Dulce Aparecida Barbosa⁴  Kelly Cristina de Lima Ramos Pinto Alves⁴  Vanessa Ribeiro Dos Santos³  Ismael Forte Freitas Junior⁵  Aline Francielle Mota Segatto¹ 

[1] Department of Physiotherapy, Univ. Estadual Paulista, Campus of Presidente Prudente, São Paulo, Brazil;Department of Physical Education, Univ. Estadual Paulista, Campus of Bauru, São Paulo, Brazil;Physical Education, Univ. Estadual Paulista, Campus of Rio Claro, São Paulo, Brazil;Department of Nursing, São Paulo Federal University, São Paulo, Brazil;Departamento de Educação Física, Universidade Estadual PaulistaUNESP, Rua Roberto Simonsen, 305 Centro Educacional, Presidente Prudente, São Paulo, CEP 19.060-900, Brasil;Sexually Transmitted Diseases Center of São Paulo State, Presidente Prudente, São Paulo, Brazil

关键词: Body composition;    Lipodysthrophy;    Abdominal obesity;    AIDS/HIV;   

Others  :  1165546
DOI  :  10.1186/1756-0500-5-543

 received in 2011-08-31, accepted in 2012-09-22,  发布年份 2012

【 摘 要 】

Background

Metabolic and morphological changes associated with excessive abdominal fat, after the introduction of Antiretroviral Therapy, increase the risk of cardiovascular disease in people living with HIV/AIDS(PLWHA). Accurate methods for body composition analysis are expensive and the use of anthropometric indices is an alternative. However the investigations about this subject in PLWHA are rare, making this research very important for clinical purpose and to advance scientific knowledge. The aim of this study is to correlate results of anthropometric indices of evaluation of body fat distribution with the results obtained by Dual-energy X-Ray Absorptiometry(DEXA), in people living with HIV/AIDS.

Methods

The sample was of 67 PLWHA(39 male and 28 female), aged 43.6

+

7.9 years. Body mass index, conicity index, waist/hip ratio, waist/height ratio and waist/thigh were calculated. Separated by sex, each index/ratio was plotted in a scatter chart with linear regression fit and their respective Pearson correlation coefficients. Analyses were performed using Prism statistical program and significance was set at 5%.

Results

The waist/height ratio presented the highest correlation coefficient, for both male (r=0.80, p<0.001) and female (r=0.87, p <001), while the lowest were in the waist/thigh also for both: male group (r=0.58, p<0.001) and female group (r=0.03, p=0.86). The other indices also showed significant positive correlation with DEXA.

Conclusion

Anthropometric indices, especially waist/height ratio may be a good alternative way to be used for evaluating the distribution of fat in the abdominal region of adults living with HIV/ADIS.

【 授权许可】

   
2012 Segatto et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Liu C, Johnson L, Ostrow D, Silvestre A, Visscher B, Jacobson LP: Predictors for lower quality of life in the HAART era among HIV-infected men. J Acquir Immune Defic Syndr. 2006, 42(4):470-77.
• [2]Scevola D, Di Matteo A, Lanzarini P, Uberti F, Scevola S, Bernini V, Spoladore G, Faga A: Effect of exercise and strength training on cardiovascular status in HIV-infected patients receiving highly active antiretroviral therapy. Aids. 2003, 17(1):123-29.
• [3]Guarald G, Murri R, Orlando G, Orlandi E, Sterrantino G, Borderi M, Grosso C, Cattelan AM, Nardini G, Beghetto B, Antinori A, Espósito R, Wu AW: Morphologic alterations in HIV- infected people with lipodystrophy are associated with good adherence to HAART. HIV clin trials. 2003, 4(2):99-106.
• [4]Guimarães MMM, Greco DB, de Ribeiro A, Penido MG, Machado LJC: Distribuição da gordura corporal e perfis lipídico e glicêmico de pacientes infectados pelo HIV. Arq Brás Endocrinol Metab. 2007, 51(1):42-51.
• [5]Florindo AA, Latorre MRDO, Santos ECD, Borelli A, Rocha MS, Segurado AAC: Validation of methods for estimating HIV/AIDS patients body fat. Rev Saude Publica. 2004, 38(5):643-49.
• [6]Carr A, Cooper DA: Adverse effects of antirretroviral therapy. Lancet 2000, 356(9239):1423-30.
• [7]Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS: Inter-relationships among childhood BMI childhood height and adult obesity: the Bogalusa Heart Study. Int J Obes. 2004, 28(1):10-6.
• [8]Aronne LJ: Classification of obesity and Assessment of Obesity-Related Health Risks. Obesity Research. 2002, 10(2):105-115.
• [9]Norgan NG: Body mass index and body energy stores in developing countries. Eur. J. din. Nutr. 1990, 44(1):79-84.
• [10]Lohman TG: Advances in body composition: current issues in exercise science series. Monograph n.3. Champaign: Human Kinetics; 1992.
• [11]Freitas IF Jr, Bueno DR, Silva CB, Codogno JS, Conterato I, Fernandes RA, Fragoso Neto RA, Messias K, Rosa CSC: Padronização de técnicas antropométricas. São Paulo: Cultura Acadêmica: Universidade Estadual Paulista, Pró reitoria de graduação; 2009.
• [12]Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD: Declining Morbidity and mortality among patients with advanced humab immunodeficiency vírus infection. N Engl J Med 1998, 338(13):858-60.
• [13]Crum NC, Riffenburgh RH, Wegner S, Agan BK, Tasker SA, Spooner KM, et al.: Comparisons of causes of death and mortality rates among HIV-infected persons. Analysis of the Pre-, early, and late HAART (highly active antiretroviral therapy) eras. J Acquir Immune Defic Syndr 2006, 41(2):194-200.
• [14]Nash D, Katyal M, Brinkhof MW, Keiser O, May M, Hughes R, et al.: Long-term immunologic response to antiretroviral therapy in low-income countries: a collaborative analysis of rospective studies. AIDS 2008, 22(17):291-302.
• [15]Mutimura E, Crowther NJ, Cadê TW, Yarasheski KE, Stewart A: Exercise training reduces central adipodity and improves metabolic índices in HAART-treated HIV-positive subjects in Rwanda: a randomized controlled trial. AIDS Res Hum Retroviruses 2008, 24(1):15-23.
• [16]Guimarães MMM, Greco DB, Ribeiro AOJ, Penido MG, Machado LJC: Distribuição da gordura corporal e perfis lipídico e glicêmico de pacientes infectados pelo HIV. Arq Bras Endocrinol Metab 2007, 51(1):42-51.
• [17]Gus M, Moreira LB, Pimentel M, Gleisener ALM, Moraes RS, Fuchs F, Fuchs FD: Associação entre diferentes indicadores de obesidade e prevalência de hipertensão arterial. Arq Bras Cardiol 1998, 70(2):111-114.
• [18]Mallon PWG, Miller J, Cooper DA, Carr A: Prospective evaluation of the effects of antiretroviral therapy on body composition in HIV-1-infected men starting therapy. AIDS 2003, 17(7):971-979.
• [19]Engelson ES, Agin D, Kenya S, Werber-Zion G, Luty B, Albu JB, Kotler DP: Body composition and metabolic effects of a diet and exercise weight loss regimen on obese, HIV-infected women. Metab Clin Exp 2006, 55(10):1327-1336.
• [20]Glaner MF: Índice de massa corporal como indicativo da gordura corporal comparado às dobras cutâneas. Rev Bras Med Esporte 2005, 11(4):243-246.
• [21]Khongsdier R: BMI and morbidity in relation to body composition: a cross-sectional study of a rural community in North-East India. Br J Nutr 2005, 93(1):101-107.
• [22]World Health Organization: Obesity. Preventing and managing the global epidemic. Geneva: World Health Organization; 1998. Report of WHO Consultation on Obesity
• [23]Monteiro CA: Epidemiologia da obesidade. In Obesidade. Edited by Halpern A, Matos AFG, Suplicy HL, Mancini MC, Zanella MT. São Paulo: Lemos Editorial; 1998:15-30.
• [24]Allison DB, Faith MS, Heo M, Kotler DP: Hypothesis concerning the U-shaped relation between body mass index and mortality. Am J Epidemiol 1997, 146(4):339-49.
• [25]Landi F, Onder G, Gambassi G, Pedone C, Carbonin P, Bernabei R: Body mass index and mortality among hospitalized patients. Arch Intern Med 2000, 160(17):2641-2644.
• [26]Diehl LA, Dias JR, Paes ACS, Thomazini MC, Garcia LR, Cinagawa E, Wiechmann SL, Carrilho AJF: Prevalência da Lipodistrofia Associada ao HIV em Pacientes Ambulatoriais Brasileiros: Relação com Síndrome Metabólica e Fatores de Risco Cardiovascular. Arq Bras Endrocrinol Metab 2008, 52(4):658-667.
• [27]Grinspoon S, Carr A: Cardiovascular risk and body-fat abnormalities in HIV-infected patients. N Engl J Med 2005, 352(1):48-62.
• [28]Padilla S, Gallego JA, Masia M, Ardoy F, Hernandez I, Gutierrez F: Ultrasonography and anthropometry for measuring regional body Fat in HIV-infected patients. Curr HIV Res 2007, 5(5):459-466.
• [29]Kahn HS: Alternative anthropometric measures of risk: possible improvements on the waist-hip ratio. In Progress in obesity research. 9ª ed edition. Edited by Medeiros-Neto G, Halpern A, Bouchard C. London: John Libbey Eurotext Ltd; 2003:639-43.
• [30]Vasques ACJ, Rosado LEFPL, Rosado GP, Ribeiro RCL, Franceschini SCC, Priore SE, Geloneze B, Oliveira DR: Indicadores do perfil lipídico plasmático relacionados à resistência à insulina. Rev Assoc Med Bras 2009, 55(3):342-346.
• [31]Pitanga FJG, Lessa I: Indicadores antropométricos de obesidade como instrumento de triagem para risco coronariano elevado em adultos na Cidade de Salvador – Hahia. Arquivos Brasileiros de Cardiologia 2005, 85(1):26-31.
• [32]Guedes DP: Recursos Antropométricos para análise da composição corporal. Revista brasileira de Educação Física, São Paulo. 2006, 20(5):115-119.
• [33]Lin WY, Lee LT, Chen CY, Lo H, Hsia HH, et al.: Optimal cut-off values for obesity: using simple anthropometric indices to predict cardiovascular risk factors in Taiwan. Int J Obes Relat Metab Disord 2002, 26(9):1232-1238.
• [34]Ho SY, Lam TH, Janus ED: Waist to stature ratio is more strongly associated with cardiovascular risk factors than other simple anthropometric indices. Ann Epidemiol 2003, 13(10):683-691.