Longitudinal association between adiposity changes and lung function deterioration

Respiratory Research

Research

Jinyeon Jo¹  Sungho Won²  Kyungsoo Chung³  Youngmok Park³  Ji Ye Jung³  Ah Young Leem³  Young Sam Kim³  Moo Suk Park³  Jiyoung Kim⁴ 

[1] Department of Public Health Sciences, School of Public Health, Seoul National University, Seoul, South Korea;Department of Public Health Sciences, School of Public Health, Seoul National University, Seoul, South Korea;Institute of Health and Environment, Seoul National University, Seoul, South Korea;RexSoft Corps, Seoul, South Korea;Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, South Korea;Yonsei University College of Medicine, Seoul, South Korea;Suwa Central Hospital, Chino-shi, Nagano, Japan;

关键词: Abdominal obesity;    Adiposity;    Body composition;    Spirometry;    Waist–hip ratio;   

DOI  :  10.1186/s12931-023-02322-8

 received in 2021-09-30, accepted in 2023-01-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population.MethodsIn total, 5011 participants (average age, 54 years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8 years), both spirometry and bio-electrical impedance analysis were performed biannually. Individual slopes of the fat mass index (FMI; fat mass divided by the square of height in meters) and waist-to-hip ratio (WHR) were calculated using linear regression analysis. Multivariate linear mixed regression analysis was used to determine the long-term association between adiposity changes and lung function.ResultsThe FMI was inversely associated with forced vital capacity (FVC) (estimated: − 31.8 mL in men, − 27.8 mL in women) and forced expiratory volume in 1 s (FEV1) (estimated: − 38.2 mL in men, − 17.8 mL in women) after adjusting for baseline age, height, residential area, smoking exposure (pack-years, men only), initial adiposity indices, and baseline lung function. The WHR was also inversely associated with FVC (estimated = − 1242.2 mL) and FEV1 (estimated = − 849.8 mL) in men. The WHR-increased group showed a more rapid decline in lung function than the WHR-decreased group in both the fat-gain and fat-loss groups.ConclusionAdiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes.

【 授权许可】

CC BY   
© The Author(s) 2023

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