Role of enteral nutrition in nonthyroidal illness syndrome: a retrospective observational study

BMC Endocrine Disorders

Jieshou Li¹  Yunzhao Zhao¹  Huajian Ren¹  Zhiwu Hong¹  Guanwei Li¹  Jun Chen¹  Xiuwen Wu¹  Gefei Wang¹  Qin Wu¹  Jianan Ren¹  Ranran Li¹ 

[1]Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhong Shan Road, Nanjing 210002, China

关键词: Enteral nutrition;    Thyroid function;    Enterocutaneous fistula;    Nonthyroidal illness syndrome;   

Others  :  1230280
DOI  :  10.1186/s12902-015-0061-y

 received in 2015-06-23, accepted in 2015-10-23,  发布年份 2015

【 摘 要 】

Background

The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS.

Methods

We conducted a retrospective observational study among patients with enterocutaneous fistula between January 2013 and April 2014. All enrolled patients received EN therapy. Thyroid function and other parameters were measured.

Results

After administration of 4 weeks of EN therapy, NTIS was resolved in 66 patients (Group A), while it persisted in 14 patients (Group B). The overall treatment success rate was 82.50 %. There were no significant differences between groups A and B at baseline for all parameters, except for the time from admission to start of EN therapy. The logistic analysis revealed that the time from admission to start of EN therapy was a significant independent indicator for achieving resolution of NTIS in our cohort.

Conclusions

This retrospective observational cohort study demonstrated that EN therapy can aid in the resolution of NTIS among patients with enterocutaneous fistula. These findings confirm the benefit of EN in the treatment of enterocutaneous fistula.

【 授权许可】

   
2015 Li et al.

【 图 表 】

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