Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study

BMC Public Health

Cyrille Delpierre¹  Thierry Lang²  Pascale Grosclaude³  David Blane⁴  Melanie Bartley⁵  Noriko Cable⁵  Rebecca Lacey⁵  Dominique Dedieu¹  Benoit Lepage²  Michelle Kelly-Irving¹ 

[1] Université Toulouse III Paul-Sabatier, UMR1027, Toulouse F-31300, France;CHU Toulouse, Hôpital Purpan, Département, Toulouse F-31300, France;Institut Claudus Regaud, Toulouse F-31300, France;Department of Primary Care and Public Health, Imperial College London, London, UK;Department of epidemiology and public health, University College London, London, UK

关键词: Life course;    Psychological stress;    Cohort studies;    Psychosocial factors;    Cancer;    (MeSH): Social medicine;   

Others  :  1161915
DOI  :  10.1186/1471-2458-13-767

 received in 2012-12-03, accepted in 2013-08-13,  发布年份 2013

【 摘 要 】

Background

To analyse whether Adverse Childhood Experiences (ACE) are associated with an increased risk of cancer.

Methods

The National child development study (NCDS) is a prospective birth cohort study with data collected over 50 years. The NCDS included all live births during one week in 1958 (n = 18558) in Great Britain. Self-reported cancer incidence was based on 444 participants reporting having had cancer at some point and 5694 reporting never having cancer. ACE was measured using reports of: 1) child in care, 2) physical neglect, 3) child’s or family’s contact with the prison service, 4) parental separation due to divorce, death or other, 5) family experience of mental illness & 6) family experience of substance abuse. The resulting variable had three categories, no ACEs/ one ACE/ 2 + ACEs and was used to test for a relationship with cancer. Information on socioeconomic characteristics, pregnancy and birth were extracted as potential confounders. Information on adult health behaviours, socioeconomic environment, psychological state and age at first pregnancy were added to the models. Multivariate models were run using multiply-imputed data to account for missing data in the cohort.

Results

The odds of having a cancer before 50 y among women increased twofold for those who had 2+ ACEs versus those with no ACEs, after adjusting for adult factors and early life confounders (OR: 2.1, 95% CI: 1.42-3.21, p < 0.001).

Conclusion

These findings suggest that cancer risk may be influenced by exposure to stressful conditions and events early on in life. This is potentially important in furthering our understanding of cancer aetiology, and consequently in redirecting scientific research and developing appropriate prevention policies.

【 授权许可】

   
2013 Kelly-Irving et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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