Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes

BMC Research Notes

Jean-Marie Pages¹  Jules R Kuiate²  Jaures A K Noumedem²  Aimé G Fankam²  Jean P Dzoyem²  Victor Kuete²  Igor K Voukeng² 

[1] Transporteurs Membranaires, Chimiorésistance et Drug Design, UMR-MD1, IFR 88, UFRs de Médecine et de Pharmacie, Marseille, France;Department of Biochemistry, Faculty of science, University of Dschang, P.O. Box 67, Dschang, Cameroon, Africa

关键词: Cameroon;    Methanol extract;    Spices;    Multi-Drug Resistant bacteria;   

Others  :  1166293
DOI  :  10.1186/1756-0500-5-299

 received in 2012-01-27, accepted in 2012-06-04,  发布年份 2012

【 摘 要 】

Background

The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.

Results

The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY).

Conclusion

The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.

【 授权许可】

   
2012 Voukeng et al.; licensee BioMed Central Ltd.

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