IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population

BMC Gastroenterology

Per G Farup³  Stian Lydersen¹  Solveig C Ligaarden² 

[1] Regional Centre for Child and Adolescent Mental Health (RBUP), Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway;Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;Department of Research, Innlandet Hospital Trust, Gjøvik, Norway

关键词: Food Hypersensitivity;    Immunoglobulin G;    Gastrointestinal tract;    Diet;    Cross-sectional studies;    Irritable bowel syndrome;    Adult;    Human;   

Others  :  858291
DOI  :  10.1186/1471-230X-12-166

 received in 2012-06-08, accepted in 2012-11-14,  发布年份 2012

【 摘 要 】

Background

Patients with Irritable Bowel Syndrome (IBS) often relate their symptoms to the intake of food and modify their diet. IgE-mediated food allergy is uncommon in IBS, but the role of IgG-mediated food hypersensitivity remains inconclusive. The primary aim of this study was to compare food- and yeast-specific IgG and IgG4 antibodies in subjects with and without IBS.

Methods

This was a case control study in the general population for which subjects completed questionnaires about abdominal complaints and their intake of common food items. Blood samples were collected, and food- and yeast-specific IgG and IgG4 antibodies were measured. Antibodies were measured in mg/L.

Results

We included 269 subjects with IBS and 277 control subjects. After correction for subject characteristics and diet, there were no significant differences with regard to food- and yeast-specific IgG and IgG4 antibodies between subjects with IBS and controls. Lower values of IgG antibodies against egg (OR 0.99 (0.98 to 1.00), p = 0.002) and beef (OR 0.75 (0.60 to 0.94), p = 0.012) and higher values of IgG antibodies against chicken (OR 1.14 (1.03 to 1.27), p = 0.009) were associated with more severe symptoms.

Conclusions

Our findings suggest that IgG-and IgG4-mediated food and yeast hypersensitivity in IBS is unlikely. IgG antibodies against food and yeast may reflect the diet.

【 授权许可】

   
2012 Ligaarden et al.; licensee BioMed Central Ltd.

【 图 表 】

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