期刊论文详细信息
BMC Research Notes
Plasma zinc levels, anthropometric and socio-demographic characteristics of school children in eastern Nepal
Nirmal Baral1  Paras Kumar Pokharel2  Madhab Lamsal1  Kisundeo Mehta1  Basanta Gelal1  Ashwini Kumar Nepal1 
[1] Department of Biochemistry, Faculty of Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal;Department of Community Medicine, Faculty of Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
关键词: Nepal;    Anthropometry;    Zinc deficiency;    Plasma zinc levels;   
Others  :  1134930
DOI  :  10.1186/1756-0500-7-18
 received in 2013-07-16, accepted in 2014-01-07,  发布年份 2014
PDF
【 摘 要 】

Background

Zinc deficiency is a major public health problem in many developing countries including Nepal. The present study was designed to assess the prevalence of zinc deficiency and to study the association of zinc deficiency with anthropometric and socio-demographic variables, in school children of eastern Nepal.

Methods

This cross-sectional study included total 125 school children of age group 6–12 years from Sunsari and Dhankuta districts of eastern Nepal. Plasma zinc level was estimated by Flame Atomic Absorption Spectroscopy.

Results

The Median interquartile range (IQR) values of zinc in the two districts Sunsari and Dhankuta were 5.9 (4.4, 7.9) μmol/L and 5.8 (4.3, 8.4) μmol/L respectively. A total of 55 children (87.3%) in Sunsari and 52 (83.9%) in Dhankuta had zinc deficiency, no significant difference was observed in the Median (IQR) plasma zinc levels (p = 0.9) and zinc deficiency patterns (p = 0.3) of the two districts. Significant differences were observed in the plasma zinc levels (p = 0.02) and zinc deficiency patterns (p = 0.001), of the school children having age groups 6–8 years than in 9–10 and 11–12 years of age, and zinc deficiency patterns between male and female school children (p = 0.04) respectively.

Conclusions

The present study showed higher prevalence of zinc deficiency among school children in eastern Nepal. In our study, zinc deficiency was associated with both sex and age. The findings from the present study will help to populate data for policy implementation regarding consumption and supplementation of zinc.

【 授权许可】

   
2014 Nepal et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20150306110717386.pdf 172KB PDF download
【 参考文献 】
  • [1]Tielsch JM, Khatry SK, Stoltzfus RJ, Katz J, LeClerq SC, Adhikari R, et al.: Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based, cluster randomised, placebo-controlled trial. Lancet 2007, 370:1230-1239.
  • [2]Chandyo RK, Strand TA, Mathisen M, Ulak M, Adhikari RK, Bolann BJ, et al.: Zinc deficiency is common among healthy women of reproductive age in Bhaktapur, Nepal. J Nutr 2009, 139:594-597.
  • [3]Fesharakinia AZA, Sharifzadeh GR: Prevalence of zinc deficiency in elementary school children of South Khorasan Province (East Iran). Iran J Pediatr 2009, 19:249-254.
  • [4]Prasad AS: Zinc: mechanisms of host defense. J Nutr 2007, 137:1345-1349.
  • [5]Basnet S, Shrestha PS, Sharma A, Mathisen M, Prasai R, Bhandari N, et al.: A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children. Pediatrics 2012, 129:701-708.
  • [6]Valentiner-Branth P, Shrestha PS, Chandyo RK, Mathisen M, Basnet S, Bhandari N, et al.: A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2–35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr 2010, 91:1667-1674.
  • [7]Surkan PJ, Shankar M, Katz J, Siegel EH, Leclerq SC, Khatry SK, et al.: Beneficial effects of zinc supplementation on head circumference of Nepalese infants and toddlers: a randomized controlled trial. Eur J Clin Nutr 2012, 66:836-842.
  • [8]Stewart CP, Christian P, LeClerq SC, West KP Jr, Khatry SK: Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal. Am J Clin Nutr 2009, 90:132-140.
  • [9]Christian P, Jiang T, Khatry SK, LeClerq SC, Shrestha SR, West KP Jr: Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal. Am J Clin Nutr 2006, 83:788-794.
  • [10]Murray-Kolb LE, Khatry SK, Katz J, Schaefer BA, Cole PM, LeClerq SC, et al.: Preschool micronutrient supplementation effects on intellectual and motor function in school-aged Nepalese children. Arch Pediatr Adolesc Med 2012, 166:404-410.
  • [11]Smith JC Jr, Butrimovitz GP, Purdy WC: Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 1979, 25:1487-1491.
  • [12]Brown KH, Rivera JA, Bhutta Z, Gibson RS, King JC, Lonnerdal B, et al.: International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 2004, 25:S99-203.
  • [13]Alarcon OM, Reinosa Fuller J, Silva TM, Angarita C, Teran E, Navas M, et al.: Serum level of Zn, Cu and Fe in healthy schoolchildren residing in Merida, Venezuela. Arch Latinoam Nutr 1997, 47:118-122.
  • [14]Ma G, Jin Y, Li Y, Zhai F, Kok FJ, Jacobsen E, Yang X: Iron and zinc deficiencies in China: what is feasible and cost-effective strategy? Public Health Nutr 2008, 11:632-638.
  • [15]Ohtake M, Tamura T: Serum zinc and copper levels in healthy Japanese children. Tohoku J Exp Med 1976, 120:99-103.
  • [16]Thurlow RA, Winichagoon P, Pongcharoen T, Gowachirapant S, Boonpraderm A, Manger MS, et al.: Risk of zinc, iodine and other micronutrient deficiencies among school children in North East Thailand. Eur J Clin Nutr 2006, 60:623-632.
  • [17]Filteau SM, Tomkins AM: Micronutrients and tropical infections. Trans R Soc Trop Med Hyg 1994, 88:1-3. 26
  • [18]Smit Vanderkooy PD, Gibson RS: Food consumption patterns of Canadian preschool children in relation to zinc and growth status. Am J Clin Nutr 1985, 45:609-616.
  • [19]Cavan KR, Gibson RS, Grazioso CF, Isalgue AM, Ruz M, Solomons NW: Growth and body composition of periurban Guatemalan children in relation to zinc status: a cross-sectional study. Am J Clin Nutr 1993, 57:334-343.
  • [20]Qin Y, Melse-Boonstra A, Zhao J, Wu M, Hu X, Kok FJ: Stunting and zinc deficiency among primary school children in rural areas with low soil zinc concentrations in Jiangsu Province, China. Asia Pac J Clin Nutr 2009, 18(1):15-21.
  • [21]Udomkesmalee E, Dhanamitta S, Yhoung-Aree J, Rojroongwasinkul N, Smith JC Jr: Biochemical evidence suggestive of suboptimal zinc and vitamin A status in schoolchildren in northeast Thailand. Am J Clin Nutr 1990, 52:564-567.
  • [22]Arvanitidou V, Voskaki I, Tripsianis G, Athanasopoulou H, Tsalkidis A, Filippidis S, et al.: Serum copper and zinc concentrations in healthy children aged 3–14 years in Greece. Biol Trace Elem Res 2007, 115:1-12.
  • [23]Singla PN, Chand P, Kumar A, Kachhawaha JS: Serum, zinc and copper levels in children with protein energy malnutrition. Indian J Pediatr 1996, 63:199-203.
  • [24]Brown KH, Peerson JM, Rivera J, Allen LH: Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2002, 75:1062-1071.
  • [25]Hettiarachchi M, Liyanage C, Wickremasinghe R, Hilmers DC, Abrahams SA: Prevalence and severity of micronutrient deficiency: a cross-sectional study among adolescents in Sri Lanka. Asia Pac J Clin Nutr 2006, 15:56-63.
  • [26]Mahmoodi MR, Kimiagar SM: Prevalence of zinc deficiency in junior high school students of Tehran City. Biol Trace Elem Res 2001, 81:93-103.
  • [27]Ndeezi G, Tumwine JK, Bolann BJ, Ndugwa CM, Tylleskar T: Zinc status in HIV infected Ugandan children aged 1–5 years: a cross sectional baseline survey. BMC Pediatr 2010, 10:68. BioMed Central Full Text
  • [28]Amare B, Moges B, Fantahun B, Tafess K, Woldeyohannes D, Yismaw G, et al.: Micronutrient levels and nutritional status of school children living in Northwest Ethiopia. Nutr J 2012, 11:108. BioMed Central Full Text
  文献评价指标  
  下载次数:9次 浏览次数:8次