How do autoimmune diseases cluster in families? A systematic review and meta-analysis

BMC Medicine

Juan-Manuel Anaya¹  Adriana Rojas-Villarraga¹  Jorge Cárdenas-Roldán¹ 

[1] Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63-C-69, Bogota, Colombia

关键词: autoimmune tautology;    genetic epidemiology;    aggregation;    familial autoimmunity;    Autoimmune diseases;   

Others  :  857141
DOI  :  10.1186/1741-7015-11-73

 received in 2012-07-24, accepted in 2013-03-18,  发布年份 2013

【 摘 要 】

Background

A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as familial autoimmune disease, has been extensively evaluated. However, aggregation of diverse autoimmune diseases, also known as familial autoimmunity, has been overlooked. Therefore, a systematic review and meta-analysis were performed aimed at gathering evidence about this topic.

Methods

Familial autoimmunity was investigated in five major autoimmune diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis and type 1 diabetes mellitus. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. Articles were searched in Pubmed and Embase databases.

Results

Out of a total of 61 articles, 44 were selected for final analysis. Familial autoimmunity was found in all the autoimmune diseases investigated. Aggregation of autoimmune thyroid disease, followed by systemic lupus erythematosus and rheumatoid arthritis, was the most encountered.

Conclusions

Familial autoimmunity is a frequently seen condition. Further study of familial autoimmunity will help to decipher the common mechanisms of autoimmunity.

【 授权许可】

   
2013 Cárdenas-Roldán et al; licensee BioMed Central Ltd.

【 图 表 】

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