Prostatic abscesses and severe sepsis due to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidin

BMC Infectious Diseases

Bruno François⁷  Anne Cypierre²  Yannis Brakbi⁴  Frédéric Laurent³  Fabien Fredon⁶  Anne-Laure Fedou⁵  Olivier Barraud¹  Maria Dubos⁵ 

[1] Microbiology laboratory, CHU Dupuytren, Limoges, France;Internal medicine department, CHU Dupuytren, Limoges, France;National Reference Centre for Staphylococci, Hospices Civils de Lyon, Bron, France;Urology department, CHU Dupuytren, Limoges, France;Intensive Care Unit, CHU Dupuytren, Limoges, France;General surgery department, CHU Dupuytren, Limoges, France;Service de Réanimation Polyvalente, Centre hospitalier universitaire Dupuytren, 2, avenue Martin Luther King, 87042 Limoges cedex, France

关键词: Severe sepsis;    Panton-valentine leukocidin;    Staphylococcus aureus;    Prostatic abscess;   

Others  :  1125735
DOI  :  10.1186/1471-2334-14-466

 received in 2014-06-04, accepted in 2014-08-19,  发布年份 2014

【 摘 要 】

Background

Prostatic abscesses are an uncommon disease usually caused by enterobacteria. They mostly occur in immunodeficient patients. It is thus extremely rare to have a Staphylococcal prostatic abscess in a young immunocompetent patient.

Case presentation

A 20-year-old patient was treated with ofloxacin for a suspicion of prostatitis. An ultrasonography was performed because of persisting symptoms and showed acute urinary retention and prostatic abscesses. So the empirical antibiotic therapy was modified with ceftriaxone/amikacin. The disease worsened to severe sepsis and the patient was admitted in ICU. CT-scan and MRI confirmed three abscesses with perirectal infiltration and the bacteriological samples (abscesses and blood cultures) were positive to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidine. The treatment was changed with fosfomycin/ofloxacin which resulted in a general improvement and the regression of the abscesses.

Conclusion

Staphyloccocus aureus producing Panton-Valentine leukocidin are most commonly responsible for skin and soft tissue infections. To this day, no other case of prostatic abscess due to this strain but susceptible to methicillin has been described.

【 授权许可】

   
2014 Dubos et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 3.

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